sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 | 1.000 | |
| 4gql | R47 | Macrophage metalloelastase | 3.4.24.65 | 0.656 | |
| 3ljg | EEF | Macrophage metalloelastase | 3.4.24.65 | 0.634 | |
| 3lik | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.631 | |
| 3lil | EEA | Macrophage metalloelastase | 3.4.24.65 | 0.600 | |
| 2woa | 576 | Macrophage metalloelastase | 3.4.24.65 | 0.599 | |
| 2wo9 | 068 | Macrophage metalloelastase | 3.4.24.65 | 0.598 | |
| 4gr0 | R4B | Macrophage metalloelastase | 3.4.24.65 | 0.591 | |
| 3tsk | QEG | Macrophage metalloelastase | 3.4.24.65 | 0.590 | |
| 4i03 | L88 | Macrophage metalloelastase | 3.4.24.65 | 0.588 | |
| 1utt | CP8 | Macrophage metalloelastase | 3.4.24.65 | 0.587 | |
| 2hu6 | 37A | Macrophage metalloelastase | 3.4.24.65 | 0.585 | |
| 3i7i | 518 | Collagenase 3 | 3.4.24 | 0.584 | |
| 3kec | 3KE | Collagenase 3 | 3.4.24 | 0.577 | |
| 3kry | 3KR | Collagenase 3 | 3.4.24 | 0.573 | |
| 1caq | DPS | Stromelysin-1 | 3.4.24.17 | 0.565 | |
| 1b8y | IN7 | Stromelysin-1 | 3.4.24.17 | 0.560 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.554 | |
| 2wo8 | 077 | Macrophage metalloelastase | 3.4.24.65 | 0.549 | |
| 3kej | 3EJ | Collagenase 3 | 3.4.24 | 0.545 | |
| 1ciz | DPS | Stromelysin-1 | 3.4.24.17 | 0.543 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.541 | |
| 4a7b | 3W5 | Collagenase 3 | 3.4.24 | 0.538 | |
| 4a7b | 3W4 | Collagenase 3 | 3.4.24 | 0.532 | |
| 3i7g | 732 | Collagenase 3 | 3.4.24 | 0.529 | |
| 4gr8 | R4C | Macrophage metalloelastase | 3.4.24.65 | 0.525 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.524 | |
| 3kek | 3EK | Collagenase 3 | 3.4.24 | 0.522 | |
| 1xud | PB4 | Collagenase 3 | 3.4.24 | 0.518 | |
| 1xur | PB5 | Collagenase 3 | 3.4.24 | 0.511 | |
| 1hov | I52 | 72 kDa type IV collagenase | 3.4.24.24 | 0.507 | |
| 4gr3 | R45 | Macrophage metalloelastase | 3.4.24.65 | 0.507 | |
| 3o2x | 3O2 | Collagenase 3 | 3.4.24 | 0.499 | |
| 1hy7 | MBS | Stromelysin-1 | 3.4.24.17 | 0.498 | |
| 2ow9 | SP6 | Collagenase 3 | 3.4.24 | 0.495 | |
| 1xuc | PB3 | Collagenase 3 | 3.4.24 | 0.493 | |
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 | 0.492 | |
| 4guy | KLJ | Macrophage metalloelastase | 3.4.24.65 | 0.492 | |
| 2d1n | FA4 | Collagenase 3 | 3.4.24 | 0.491 | |
| 1c8t | TR1 | Stromelysin-1 | 3.4.24.17 | 0.474 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.457 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.455 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.455 | |
| 4h76 | 10B | Macrophage metalloelastase | 3.4.24.65 | 0.453 | |
| 1g4k | HQQ | Stromelysin-1 | 3.4.24.17 | 0.452 | |
| 2ow0 | 6MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.452 | |
| 5dbf | NDP | Iridoid synthase | 1.3.1.99 | 0.452 | |
| 5dp2 | NAP | CurF | / | 0.452 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.446 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.446 | |
| 4g9l | NGH | Stromelysin-1 | 3.4.24.17 | 0.446 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.445 | |
| 2ovz | 5MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.445 | |
| 4fco | 0U4 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.443 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.443 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.443 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.443 | |
| 1ha3 | MAU | Elongation factor Tu-A | / | 0.442 | |
| 2d1o | FA4 | Stromelysin-1 | 3.4.24.17 | 0.442 | |
| 2ow1 | 7MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.442 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.442 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.442 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.442 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.441 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.441 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.440 |