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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3tn7NJPShort-chain alcohol dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3tn7NJPShort-chain alcohol dehydrogenase/1.000
3l77NJPShort-chain alcohol dehydrogenase/0.642
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.548
1xg5NAPDehydrogenase/reductase SDR family member 11/0.541
1xkqNDPUncharacterized protein/0.528
3p19NDPPutative blue fluorescent protein/0.526
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.494
4hwkNAPSepiapterin reductase1.1.1.1530.491
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.490
1ae1NAPTropinone reductase 1/0.488
5idwNAPShort-chain dehydrogenase/reductase SDR/0.483
4qecNAPElxO/0.482
1oaaNAPSepiapterin reductase1.1.1.1530.478
1x7gNAPPutative ketoacyl reductase1.3.10.478
4j7xNAPSepiapterin reductase1.1.1.1530.478
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.474
2bd0NAPSepiapterin reductase/0.474
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.474
4j7uNAPSepiapterin reductase1.1.1.1530.473
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.470
3qrwNDPPutative ketoacyl reductase1.3.10.470
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.469
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.468
1ipeNDPTropinone reductase 21.1.1.2360.466
4esoNAPPutative oxidoreductase/0.466
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.464
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.464
1x7hNDPPutative ketoacyl reductase1.3.10.459
3sjuNDPKeto reductase/0.459
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.457
1snyNAPLD36273p/0.455
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.455
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
4qedNAPElxO/0.454
1g6kNADGlucose 1-dehydrogenase1.1.1.470.453
4bmvNAPShort-chain dehydrogenase/0.453
3s5wFADL-ornithine N(5)-monooxygenase/0.452
3uceNDPDehydrogenase/0.452
3toxNAPPutative oxidoreductase/0.451
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.450
2x6tNAPADP-L-glycero-D-manno-heptose-6-epimerase/0.448
2yutNAPPutative short-chain oxidoreductase/0.448
4dc1NDPPutative ketoacyl reductase1.3.10.448
1rwbNADGlucose 1-dehydrogenase1.1.1.470.447
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.447
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.447
2jahNDPClavaldehyde dehydrogenase/0.446
3d3wNAPL-xylulose reductase1.1.1.100.446
3gy0NAPNAD(P)-dependent oxidoreductase/0.444
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.444
1n5dNDPCarbonyl reductase [NADPH] 1/0.443
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.440