sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 1.000 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.643 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.579 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.489 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.488 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.488 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.484 | |
| 4k9v | 6AW | Cytochrome P450 3A4 | / | 0.484 | |
| 2vnk | FAD | NADPH:ferredoxin reductase | / | 0.481 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.481 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.478 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.478 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.477 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.477 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.475 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.474 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.474 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.470 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.470 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.469 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.465 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.464 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.460 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.459 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.457 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.457 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.457 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.456 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.455 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.453 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.452 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.451 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.449 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.448 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.447 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.447 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.445 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.443 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.441 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.440 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 |