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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3t99ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3t99ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/1.000
3t9aANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.620
4nzoANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.565
3t9fADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.563
3t9eADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.560
3t9dANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.558
3t54ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.548
4q4cADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.534
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.490
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.482
1qmzATPCyclin-dependent kinase 22.7.11.220.467
4fzvSAM5-methylcytosine rRNA methyltransferase NSUN42.1.10.467
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.466
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.463
4qnyANPMitogen activated protein kinase, putative/0.461
2xclANPPhosphoribosylamine--glycine ligase/0.460
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.458
2cduFADNADH oxidase/0.458
5cnnANPEpidermal growth factor receptor2.7.10.10.457
1f8wFADNADH peroxidase1.11.1.10.454
1jstATPCyclin-dependent kinase 22.7.11.220.454
1w49APCNTPase P4/0.453
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.452
4e5yNDPGDP-L-fucose synthase1.1.1.2710.452
4ii5ADPCyclin-dependent kinase 22.7.11.220.452
2yxlSFG450aa long hypothetical fmu protein/0.449
3r8vZ62Cyclin-dependent kinase 22.7.11.220.449
4a6cQG9Gag-Pol polyprotein3.4.23.160.449
1nhrFADNADH peroxidase1.11.1.10.448
2nliFMNLactate oxidase/0.448
3ggu017Gag-Pol polyprotein3.4.23.160.448
4gyiADPUncharacterized protein/0.447
3vfa031Gag-Pol polyprotein3.4.23.160.446
1b38ATPCyclin-dependent kinase 22.7.11.220.445
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.444
3el51UNGag-Pol polyprotein/0.444
1bv9XV6Gag-Pol polyprotein3.4.23.160.443
2pym1UNGag-Pol polyprotein3.4.23.160.443
3wo1ADPAlanine--anticapsin ligase/0.443
1d4jMSCGag-Pol polyprotein3.4.23.160.442
1npvL27Gag-Pol polyprotein3.4.23.160.442
5kgpACOPredicted acetyltransferase/0.442
1osvCHCBile acid receptor/0.441
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.440
1nzdUPGDNA beta-glucosyltransferase/0.440