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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3t74UBYThermolysin3.4.24.27

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3t74UBYThermolysin3.4.24.271.000
3t8hUBSThermolysin3.4.24.270.822
3t8dUBVThermolysin3.4.24.270.820
4h570PJThermolysin3.4.24.270.645
6tmn0PIThermolysin3.4.24.270.633
3t8cUBWThermolysin3.4.24.270.626
3t87UBZThermolysin3.4.24.270.622
4d9wX32Thermolysin3.4.24.270.617
4tmn0PKThermolysin3.4.24.270.616
4tlnLNOThermolysin3.4.24.270.590
2tmn0FAThermolysin3.4.24.270.568
4b52RDFBacillolysin/0.520
1qf2TI3Thermolysin3.4.24.270.515
3fgdBYAThermolysin3.4.24.270.490
3forZNPThermolysin3.4.24.270.488
4ca53EFAngiotensin-converting enzyme3.2.10.460
2hpvFMNFMN-dependent NADH-azoreductase1.70.457
3q43D66M1 family aminopeptidase3.4.110.452
1c7oPPGHemolysin/0.448
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.442
4zr5RDFNeprilysin/0.442
1qbqHFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.441
1qbqHFPProtein farnesyltransferase subunit beta2.5.1.580.441
1obnASVIsopenicillin N synthase1.21.3.10.440