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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3r8hZOMAldo-keto reductase family 1 member C3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3r8hZOMAldo-keto reductase family 1 member C3/1.000
4h7c10HAldo-keto reductase family 1 member C3/0.602
1ry0PG2Aldo-keto reductase family 1 member C3/0.601
3ug8IMNAldo-keto reductase family 1 member C3/0.601
1ry8RUTAldo-keto reductase family 1 member C3/0.588
3ugrIMNAldo-keto reductase family 1 member C3/0.582
4fa30SLAldo-keto reductase family 1 member C3/0.571
3uweVJJAldo-keto reductase family 1 member C3/0.566
4dbw511Aldo-keto reductase family 1 member C3/0.564
2f3815MAldo-keto reductase family 1 member C3/0.560
4dbuBT9Aldo-keto reductase family 1 member C3/0.558
3r94FLRAldo-keto reductase family 1 member C3/0.557
3r43ID8Aldo-keto reductase family 1 member C3/0.554
3r7mSUZAldo-keto reductase family 1 member C3/0.550
3r8gIZPAldo-keto reductase family 1 member C3/0.539
4hmn16JAldo-keto reductase family 1 member C3/0.533
4fam0SZAldo-keto reductase family 1 member C3/0.528
1s2cFLFAldo-keto reductase family 1 member C3/0.526
4fal0T0Aldo-keto reductase family 1 member C3/0.523
3ufyNPXAldo-keto reductase family 1 member C3/0.512
3r6iJMSAldo-keto reductase family 1 member C3/0.502
4dbs0HVAldo-keto reductase family 1 member C3/0.481
2xuiTZ5Acetylcholinesterase3.1.1.70.480
3r58NPSAldo-keto reductase family 1 member C3/0.478
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.475
4m0f1YKAcetylcholinesterase3.1.1.70.472
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.461
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.461
2xuhTZ4Acetylcholinesterase3.1.1.70.460
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.458
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.458
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.457
2geuCOKPantothenate kinase2.7.1.330.456
2w6cBM4Acetylcholinesterase3.1.1.70.455
4bfxZVXPantothenate kinase2.7.1.330.455
2xupTZ5Acetylcholinesterase3.1.1.70.453
4bfvZVVPantothenate kinase2.7.1.330.452
4ey7E20Acetylcholinesterase3.1.1.70.452
1w6rGNTAcetylcholinesterase3.1.1.70.451
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.451
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.451
2xujTZ5Acetylcholinesterase3.1.1.70.451
4bftZVTPantothenate kinase2.7.1.330.451
1eveE20Acetylcholinesterase3.1.1.70.450
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.449
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.449
4bfsZVSPantothenate kinase2.7.1.330.449
2getCOKPantothenate kinase2.7.1.330.447
2zsdCOAPantothenate kinase2.7.1.330.447
3k1wBFXRenin3.4.23.150.446
3v94WYQPhosphodiesterase/0.446
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.444
2jf0HBPAcetylcholinesterase3.1.1.70.443
1h22E10Acetylcholinesterase3.1.1.70.442
4zvnFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.442
4arbC57Acetylcholinesterase3.1.1.70.441
2ckmAA7Acetylcholinesterase3.1.1.70.440
2gesCOKPantothenate kinase2.7.1.330.440
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.440