sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3qck | NX5 | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3qck | NX5 | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 1.000 | |
| 3qcl | NXV | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.633 | |
| 3qci | NX3 | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.595 | |
| 3qch | NX2 | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.582 | |
| 3qcm | NXW | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.555 | |
| 3qcj | NX4 | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.535 | |
| 3qce | NXY | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.517 | |
| 3qcf | NXY | Receptor-type tyrosine-protein phosphatase gamma | 3.1.3.48 | 0.510 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.481 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.465 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.460 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.458 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.452 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.451 | |
| 2wes | FAD | Tryptophan 5-halogenase | / | 0.450 | |
| 4ict | 1ED | Mycocyclosin synthase | 1.14.21.9 | 0.450 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.448 | |
| 5bn3 | ADP | V-type ATP synthase alpha chain | / | 0.445 | |
| 5bn3 | ADP | NEQ263 | / | 0.445 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 4c2j | COA | 3-ketoacyl-CoA thiolase, mitochondrial | 2.3.1.16 | 0.444 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.443 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.441 | |
| 2wpw | ACO | Orf14 | / | 0.441 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.441 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.441 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.441 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.440 |