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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3q65NAPAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3q65NAPAldose reductase1.1.1.211.000
3q67NAPAldose reductase1.1.1.210.728
2acqNAPAldose reductase1.1.1.210.512
2j8tNAPAldose reductase1.1.1.210.510
2iq0NAPAldose reductase1.1.1.210.508
1x96NAPAldose reductase1.1.1.210.507
1z8aNAPAldose reductase1.1.1.210.495
3v36NAPAldose reductase1.1.1.210.492
2pfhNDPAldose reductase1.1.1.210.482
2pevNDPAldose reductase1.1.1.210.477
2pf8NDPAldose reductase1.1.1.210.477
1ah4NAPAldose reductase1.1.1.210.468
1x98NAPAldose reductase1.1.1.210.467
1az2NAPAldose reductase1.1.1.210.462
2hejNDPAldo-keto reductase family 1 member C211.1.10.462
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.455
1adsNAPAldose reductase1.1.1.210.454
3h7rNAPAldo-keto reductase family 4 member C8/0.448
2acsNAPAldose reductase1.1.1.210.444