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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3npcB96Mitogen-activated protein kinase 92.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3npcB96Mitogen-activated protein kinase 92.7.11.241.000
3nnuEDBMitogen-activated protein kinase 14/0.559
3lfbZ87Mitogen-activated protein kinase 14/0.546
3uvr06FMitogen-activated protein kinase 14/0.542
3gcuR48Mitogen-activated protein kinase 14/0.533
3hv4L51Mitogen-activated protein kinase 14/0.531
3p7bP7BMitogen-activated protein kinase 14/0.528
3p7aP7AMitogen-activated protein kinase 14/0.524
2yisYISMitogen-activated protein kinase 14/0.513
3nnxEDDMitogen-activated protein kinase 14/0.506
3p5kP5KMitogen-activated protein kinase 14/0.506
1kv2B96Mitogen-activated protein kinase 14/0.505
3hv71AUMitogen-activated protein kinase 14/0.501
1wbtWBTMitogen-activated protein kinase 14/0.498
3nnwEDDMitogen-activated protein kinase 14/0.497
1w82L10Mitogen-activated protein kinase 14/0.496
3p7cP7CMitogen-activated protein kinase 14/0.492
1wbsLI2Mitogen-activated protein kinase 14/0.489
3d83GK6Mitogen-activated protein kinase 14/0.488
2puuG2GMitogen-activated protein kinase 14/0.482
3hv6R39Mitogen-activated protein kinase 14/0.481
4f7n0SVCyclin-dependent kinase 82.7.11.220.479
3e9319BMitogen-activated protein kinase 14/0.477
3hv5R24Mitogen-activated protein kinase 14/0.477
3p79P79Mitogen-activated protein kinase 14/0.476
3k3jF4CMitogen-activated protein kinase 14/0.475
3lffZ83Mitogen-activated protein kinase 14/0.475
1kv1BMUMitogen-activated protein kinase 14/0.469
1a71NADAlcohol dehydrogenase E chain1.1.1.10.465
1axeNADAlcohol dehydrogenase E chain1.1.1.10.462
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2yiwYIWMitogen-activated protein kinase 14/0.456
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3cs9NILTyrosine-protein kinase ABL12.7.10.20.452
1wbvLI3Mitogen-activated protein kinase 14/0.451
3p78P78Mitogen-activated protein kinase 14/0.451
3lfqA28Cyclin-dependent kinase 22.7.11.220.449
1sx4ADP60 kDa chaperonin/0.448
2q1l8823-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.448
4hgt15GCasein kinase I isoform delta2.7.11.10.448
4dwvNAJAlcohol dehydrogenase E chain1.1.1.10.446
1r0zATPCystic fibrosis transmembrane conductance regulator/0.445
1adbCNDAlcohol dehydrogenase E chain1.1.1.10.444
3gcvSS6Mitogen-activated protein kinase 14/0.444
2jhfNADAlcohol dehydrogenase E chain1.1.1.10.443
4f6s0SQCyclin-dependent kinase 82.7.11.220.442
1n07FMNRiboflavin kinase2.7.1.260.441
4l8mF46Mitogen-activated protein kinase 14/0.441
2bxiAZQSerum albumin/0.440