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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3nbwTR4Ketohexokinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3nbwTR4Ketohexokinase/1.000
3nc9TR3Ketohexokinase/0.647
3q92XNBKetohexokinase/0.606
2hw1ANPKetohexokinase/0.595
3qa2XNAKetohexokinase/0.594
3qaiXNNKetohexokinase/0.588
3nbvANPKetohexokinase/0.564
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.467
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.465
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.460
1gqtACPRibokinase/0.459
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.454
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.453
2vx07X7Ephrin type-B receptor 42.7.10.10.451
3vryB43Tyrosine-protein kinase HCK2.7.10.20.449
4s1b2BALmo1466 protein/0.448
3mvl38PMitogen-activated protein kinase 14/0.447
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.447
1k6tXN1Gag-Pol polyprotein3.4.23.160.446
3so9017Pol protein/0.445
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.445
4aicNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.444
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.443
4lopSB4Mitogen-activated protein kinase 14/0.443
4looSB4Mitogen-activated protein kinase 14/0.442
2xynVX6Abelson tyrosine-protein kinase 22.7.10.20.440