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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3litE15Protease

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3litE15Protease/1.000
3livE16Protease/0.781
3liqE14Protease/0.761
3linE13Protease/0.639
3wsjMK1Protease/0.578
2xyfG40Gag-Pol polyprotein/0.534
3lixE17Protease/0.526
2xyeCXGGag-Pol polyprotein/0.523
3el51UNGag-Pol polyprotein/0.521
2nnkROCProtease/0.519
3ggxGGXGag-Pol polyprotein/0.519
1hvlA76Gag-Pol polyprotein/0.518
3ekwDR7Gag-Pol polyprotein3.4.23.160.517
1d4yTPVGag-Pol polyprotein3.4.23.160.516
1hvjA78Gag-Pol polyprotein/0.516
1wbk568Pol protein/0.516
3bgbLJGGag-Pol polyprotein3.4.23.160.516
4hdfG52Gag-Pol polyprotein3.4.23.160.515
3zptM8YGag-Pol polyprotein3.4.23.160.514
3ekp478Gag-Pol polyprotein3.4.23.160.513
2aquDR7Gag-Pol polyprotein3.4.23.160.512
1ohr1UNV-1 PROTEASE protein/0.511
2ieo017Protease/0.511
4a6cQG9Gag-Pol polyprotein3.4.23.160.511
1difA85Gag-Pol polyprotein/0.510
3kdcJZPGag-Pol polyprotein3.4.23.160.509
1hpxKNIGag-Pol polyprotein/0.508
1rl8RITGag-Pol polyprotein3.4.23.160.508
1w5yBE6Gag-Pol polyprotein3.4.23.160.508
2aoe0Q4Gag-Pol polyprotein3.4.23.160.508
2fxeDR7Gag-Pol polyprotein3.4.23.160.508
4a6bQG8Gag-Pol polyprotein3.4.23.160.508
4ye3G04Gag-Pol polyprotein3.4.23.160.508
1hvsA77Gag-Pol polyprotein/0.507
2cem2AHPol protein/0.507
2fxdDR7Pol polyprotein/0.507
1vikBAYGag-Pol polyprotein/0.506
4njvRITProtease/0.506
3em4DR7Gag-Pol polyprotein3.4.23.160.505
3ggaGGWGag-Pol polyprotein/0.505
1ec2BEJGag-Pol polyprotein3.4.23.160.504
1ec3MS3Gag-Pol polyprotein3.4.23.160.504
3ekqROCGag-Pol polyprotein3.4.23.160.504
3kf03TLGag-Pol polyprotein/0.504
3nxe2NCProtease/0.504
2fdd385Pol protein/0.503
4djr0KJPol polyprotein/0.503
2p3b3TLV-1 PROTEASE protein/0.502
2p3b3TLV-1 protease/0.502
3oxcROCProtease/0.502
4kb9G79Protease/0.502
1k2b0Q4Gag-Pol polyprotein3.4.23.160.501
2pk6O33V-1 protease/0.501
3ndwRITGag-Pol polyprotein3.4.23.160.501
3ndxRITGag-Pol polyprotein3.4.23.160.501
1hsgMK1Gag-Pol polyprotein/0.500
1iiq0ZRGag-Pol polyprotein3.4.23.160.500
1z1hHBBGag-Pol polyprotein3.4.23.160.500
2avvMK1Gag-Pol polyprotein3.4.23.160.500
2rkfAB1Pol protein/0.500
3kfr3TLGag-Pol polyprotein/0.500
3sa755AProtease/0.500
2wl05AHGag-Pol polyprotein/0.499
3fx5KNIGag-Pol polyprotein3.4.23.160.499
3oxxDR7Gag-Pol polyprotein3.4.23.160.499
3tl9ROCGag-Pol polyprotein3.4.23.160.499
3vfa031Gag-Pol polyprotein3.4.23.160.499
2cen4AHProtease/0.498
2uxzHI1Gag-Pol polyprotein3.4.23.160.498
1d4kPI8Gag-Pol polyprotein3.4.23.160.497
1ivp1ZKGag-Pol polyprotein/0.497
2nmyROCProtease/0.497
3dk1G05Gag-Pol polyprotein3.4.23.160.497
1hvkA79Gag-Pol polyprotein/0.496
3a2oKNJGag-Pol polyprotein3.4.23.160.496
1bwaXV6Gag-Pol polyprotein3.4.23.160.495
2bpw1INGag-Pol polyprotein3.4.23.160.495
3el9DR7Gag-Pol polyprotein3.4.23.160.495
3hzc2NCProtease/0.495
4j5j478Gag-Pol polyprotein3.4.23.160.495
1c6zROCProtease/0.494
2a4fAAUV-1 protease/0.494
3bgcLJHGag-Pol polyprotein3.4.23.160.494
3el1DR7Gag-Pol polyprotein3.4.23.160.494
1t7i017Gag-Pol polyprotein3.4.23.160.493
3ndtROCGag-Pol polyprotein3.4.23.160.493
4djoMK5Pol polyprotein/0.493
4hdpG52Gag-Pol polyprotein3.4.23.160.493
4qgiROCGag-Pol polyprotein3.4.23.160.493
2f3kRO1Protease/0.492
2qi3MZ5Gag-Pol polyprotein/0.492
3zpsEQMGag-Pol polyprotein3.4.23.160.492
1odw0E8Gag-Pol polyprotein3.4.23.160.491
2bpv1INGag-Pol polyprotein3.4.23.160.491
2qnqQN3Gag-Pol polyprotein3.4.23.160.491
3oxv478Gag-Pol polyprotein3.4.23.160.491
3s85LK0Gag-Pol polyprotein/0.491
4hdbG52Gag-Pol polyprotein3.4.23.160.491
4j55031Gag-Pol polyprotein3.4.23.160.491
1b6kPI5Gag-Pol polyprotein3.4.23.160.490
1bv7XV6Gag-Pol polyprotein3.4.23.160.490
1zsr0ZTGag-Pol polyprotein3.4.23.160.490
2b7zMK1Gag-Pol polyprotein/0.490
2o4pTPVProtease/0.490
2p3d3TLProtease/0.490
2uy0HV1Gag-Pol polyprotein3.4.23.160.490
4a4qUX9Pol protein/0.490
1a9mU0EGag-Pol polyprotein/0.489
1jld0PPGag-Pol polyprotein/0.489
1k1u0Q4Gag-Pol polyprotein3.4.23.160.489
2nnpROCProtease/0.489
3nu9478Gag-Pol polyprotein3.4.23.160.489
3zpuM8BGag-Pol polyprotein3.4.23.160.489
4djqM86Pol polyprotein/0.489
1hxwRITGag-Pol polyprotein/0.488
2qd6065Gag-Pol polyprotein3.4.23.160.488
3k4vROCGag-Pol polyprotein3.4.23.160.488
3s54017Protease/0.488
1zsf0ZSGag-Pol polyprotein3.4.23.160.487
3kfn3TLGag-Pol polyprotein/0.487
3nyg2NCGag-Pol polyprotein3.4.23.160.487
4rvj478Protease/0.487
1fgc2NCGag-Pol polyprotein3.4.23.160.486
2fde385Gag-Pol polyprotein3.4.23.160.486
2wkz5AHGag-Pol polyprotein/0.486
3ekyDR7Gag-Pol polyprotein3.4.23.160.486
1b6pPI7Gag-Pol polyprotein3.4.23.160.485
1d4sTPVGag-Pol polyprotein3.4.23.160.485
1hviA77Protease/0.485
2bqvA1AProtease/0.485
2qhcAB1Protease/0.485
3d1yROCGag-Pol polyprotein3.4.23.160.485
3nduROCGag-Pol polyprotein3.4.23.160.485
3ok9G52Gag-Pol polyprotein3.4.23.160.485
3el4ROCGag-Pol polyprotein3.4.23.160.484
3sa323XProtease/0.484
1a8k0Q4Gag-Pol polyprotein3.4.23.160.483
1ida0POGag-Pol polyprotein3.4.23.470.483
1sbgIM1Gag-Pol polyprotein/0.483
1t7kBH0Gag-Pol polyprotein3.4.23.160.483
2bb9AKCGag-Pol polyprotein3.4.23.160.483
2bpy3INGag-Pol polyprotein3.4.23.160.483
2idw017Protease/0.483
3sabF78Protease/0.482
1bwb146Gag-Pol polyprotein3.4.23.160.481
2bpz3INGag-Pol polyprotein3.4.23.160.481
2i4xKGQProtease/0.481
3cyxROCGag-Pol polyprotein3.4.23.160.481
3i2l2NCProtease/0.481
3sa4F72Protease/0.481
3sacAF8Protease/0.481
1hihC20Gag-Pol polyprotein/0.480
2pk5075Protease/0.480
3d1xROCGag-Pol polyprotein3.4.23.160.480
3ekt017Gag-Pol polyprotein3.4.23.160.480
3em6017Gag-Pol polyprotein3.4.23.160.480
3s43478Protease/0.480
3vfb031Gag-Pol polyprotein3.4.23.160.480
1d4hBEHGag-Pol polyprotein3.4.23.160.479
2qak1UNGag-Pol polyprotein3.4.23.160.479
2qd8065Gag-Pol polyprotein3.4.23.160.479
2qi5MZ7Gag-Pol polyprotein/0.479
3slz3TLPutative gag-pro-pol polyprotein/0.479
4njuTPVProtease/0.479
2a1eIPFGag-Pol polyprotein3.4.23.160.478
3i7eDJRGag-Pol polyprotein/0.478
3kfs3TLGag-Pol polyprotein/0.478
3t3c017Gag-Pol polyprotein3.4.23.160.478
3uhl2NCGag-Pol polyprotein3.4.23.160.478
1wbmBLLPol protein/0.477
2qnnQN1Gag-Pol polyprotein3.4.23.160.477
1ffi2NCGag-Pol polyprotein3.4.23.160.476
1hxbROCGag-Pol polyprotein3.4.23.160.476
1sguMK1Gag-Pol polyprotein3.4.23.160.476
1xl5190Gag-Pol polyprotein3.4.23.160.476
1dw60Q4Gag-Pol polyprotein3.4.23.160.475
3d1z017Gag-Pol polyprotein3.4.23.160.475
3sa9A68Protease/0.475
4dfg0JVGag-Pol polyprotein3.4.23.160.475
1daz0Q4Gag-Pol polyprotein3.4.23.160.474
1t3r017Gag-Pol polyprotein3.4.23.160.474
3mxeK54Gag-Pol polyprotein3.4.23.160.474
3sa5A69Protease/0.474
1ec0BEDGag-Pol polyprotein3.4.23.160.473
1sdvMK1Gag-Pol polyprotein3.4.23.160.473
2i4uDJRProtease/0.473
2i4wKGQProtease/0.473
2qd7065Gag-Pol polyprotein3.4.23.160.473
1bai0Q4Gag-Pro polyprotein/0.472
1ebwBEIGag-Pol polyprotein3.4.23.160.472
1hiv1ZKGag-Pol polyprotein/0.472
1npvL27Gag-Pol polyprotein3.4.23.160.472
1yt9OISGag-Pol polyprotein/0.472
2f81017Gag-Pol polyprotein3.4.23.160.472
2q3kMUWGag-Pol polyprotein/0.472
2q5kAB1Protease/0.472
2r43G3GGag-Pol polyprotein3.4.23.160.472
3cktYDPGag-Pol polyprotein3.4.23.160.472
1b6mPI6Gag-Pol polyprotein3.4.23.160.471
1d4iBEGGag-Pol polyprotein3.4.23.160.471
1fg62NCGag-Pol polyprotein3.4.23.160.471
1msmJE2Gag-Pol polyprotein3.4.23.160.471
2p3a3TLPol protein/0.471
3jw2017Gag-Pol polyprotein3.4.23.160.471
4k4p3TLGag-Pol polyprotein/0.471
1b6lPI4Gag-Pol polyprotein3.4.23.160.470
1hshMK1Gag-Pol polyprotein/0.470
3o9cK20Pol polyprotein/0.470
3pwrROCGag-Pol polyprotein3.4.23.160.470
3vf5031Gag-Pol polyprotein3.4.23.160.470
4njt017Protease/0.470
1ec1BEEGag-Pol polyprotein3.4.23.160.469
1fg80Q4Gag-Pol polyprotein3.4.23.160.469
1iziQ50Gag-Pol polyprotein3.4.23.160.469
1mtrPI6Gag-Pol polyprotein3.4.23.160.469
1z1rHBHGag-Pol polyprotein3.4.23.160.469
2f8g017Gag-Pol polyprotein3.4.23.160.469
2pyn1UNGag-Pol polyprotein3.4.23.160.469
3djkG55Gag-Pol polyprotein3.4.23.160.469
3saa77FProtease/0.469
1sdtMK1Gag-Pol polyprotein3.4.23.160.468
2avm2NCGag-Pol polyprotein3.4.23.160.468
2f80017Gag-Pol polyprotein3.4.23.160.468
2hb3GRLProtease/0.468
1c6x3INProtease/0.467
1t7j478Gag-Pol polyprotein3.4.23.160.467
1vijBAYGag-Pol polyprotein/0.467
1w5vBE3Gag-Pol polyprotein3.4.23.160.467
3gi4K60Gag-Pol polyprotein/0.467
3ufnROCGag-Pol polyprotein/0.467
4hegG52Gag-Pol polyprotein3.4.23.160.467
1msnJE2Gag-Pol polyprotein3.4.23.160.466
1npa3NHGag-Pol polyprotein3.4.23.160.466
1npwLGZGag-Pol polyprotein3.4.23.160.466
2i4vDJRV-1 protease/0.466
3cyw017Gag-Pol polyprotein3.4.23.160.466
3dcrKVSProtease/0.466
3gi6D78Gag-Pol polyprotein/0.466
3oy4017Gag-Pol polyprotein3.4.23.160.466
4djpM73Pol polyprotein/0.466
1qbsDMPGag-Pol polyprotein3.4.23.160.465
1tcxIM1Gag-Pol polyprotein3.4.23.160.465
2i0dMUTProtease/0.465
2qi7MZ9Gag-Pol polyprotein/0.465
3nwq2NCGag-Pol polyprotein3.4.23.160.465
3ttp017Gag-Pol polyprotein3.4.23.160.465
1w5xBE5Gag-Pol polyprotein3.4.23.160.464
2cej1AHPol protein/0.464
2pwcG3GGag-Pol polyprotein3.4.23.160.464
2r5pMK1Gag-Pol polyprotein/0.464
3ekx1UNGag-Pol polyprotein3.4.23.160.464
3jvwDMPGag-Pol polyprotein3.4.23.160.464
3nuo478Gag-Pol polyprotein3.4.23.160.464
3st5G89Gag-Pol polyprotein3.4.23.160.464
9hvp0E9Gag-Pol polyprotein/0.464
3nu4478Gag-Pol polyprotein3.4.23.160.463
3s56ROCProtease/0.463
4dqc017Gag-Pol polyprotein/0.463
1d4jMSCGag-Pol polyprotein3.4.23.160.462
2avsMK1Gag-Pol polyprotein3.4.23.160.462
2hc0AB2Protease/0.462
2qci065Gag-Pol polyprotein3.4.23.160.462
3em3478Gag-Pol polyprotein3.4.23.160.462
3o9iA61Gag-Pol polyprotein/0.462
3qp0NI8Gag-Pol polyprotein3.4.23.160.462
3sa6F71Protease/0.462
3sa8K83Protease/0.462
1c6yMK1Protease/0.461
2pym1UNGag-Pol polyprotein3.4.23.160.461
2q641UNGag-Pol polyprotein3.4.23.160.461
2qnpQN2Gag-Pol polyprotein3.4.23.160.461
2r5q1UNGag-Pol polyprotein/0.461
2z54AB1Gag-Pol polyprotein3.4.23.160.461
3ggu017Gag-Pol polyprotein3.4.23.160.461
3tog079Gag-Pol polyprotein2.7.7.490.461
1k6vXN2Gag-Pol polyprotein3.4.23.160.460
2aidTHKGag-Pol polyprotein3.4.23.160.460
2upjU02Gag-Pol polyprotein3.4.23.160.460
3aidARQGag-Pol polyprotein3.4.23.160.460
3jvy017Gag-Pol polyprotein3.4.23.160.460
3mws017Pol protein/0.460
4i8zG08Gag-Pol polyprotein3.4.23.160.460
1c70L75Protease/0.459
2hs2017Protease/0.459
3qrsNK8Gag-Pol polyprotein3.4.23.160.459
1d4lPI9Gag-Pol polyprotein3.4.23.160.458
1ff02NCGag-Pol polyprotein3.4.23.160.458
1hiiC20Gag-Pol polyprotein/0.458
1mrwK57Gag-Pol polyprotein3.4.23.160.458
2q631UNGag-Pol polyprotein3.4.23.160.458
3qbfJHGGag-Pol polyprotein3.4.23.160.458
3qn8NI7Gag-Pol polyprotein3.4.23.160.458
4q1y017Gag-Pol polyprotein3.4.23.160.458
2pqzG0GGag-Pol polyprotein3.4.23.160.457
3gi5K62Gag-Pol polyprotein/0.457
3ucb017Gag-Pol polyprotein/0.457
1hpoUNIGag-Pol polyprotein3.4.23.160.456
1idb0DOGag-Pol polyprotein/0.456
1kzkJE2Gag-Pol polyprotein3.4.23.160.456
2ien017Gag-Pol polyprotein3.4.23.160.456
2qhzMZ2Gag-Pol polyprotein/0.456
3nwxKVSGag-Pol polyprotein3.4.23.160.456
3o9bK2APol polyprotein/0.456
1ebyBEBGag-Pol polyprotein3.4.23.160.455
1muiAB1Protease/0.455
2hs1017Protease/0.455
3qpjN4IGag-Pol polyprotein3.4.23.160.455
1sh9RITGag-Pol polyprotein3.4.23.160.454
1izhQ50Protease/0.453
1n49RITGag-Pol polyprotein3.4.23.160.453
2qi0MZ3Gag-Pol polyprotein/0.453
3o9gF53Gag-Pol polyprotein/0.453
3qrmNK7Gag-Pol polyprotein3.4.23.160.453
1a8g2Z4Gag-Pol polyprotein3.4.23.160.452
1fej2NCGag-Pol polyprotein3.4.23.160.452
1g35AHFGag-Pol polyprotein3.4.23.160.452
1hosPHPGag-Pol polyprotein/0.452
2qi4MZ6Gag-Pol polyprotein/0.452
2qi6MZ8Gag-Pol polyprotein/0.452
3el01UNGag-Pol polyprotein3.4.23.160.452
3kddJZQGag-Pol polyprotein3.4.23.160.452
3o9dK19Pol polyprotein/0.452
1k2c0Q4Gag-Pol polyprotein3.4.23.160.451
1mesDMPGag-Pol polyprotein3.4.23.160.451
1qbu846Gag-Pol polyprotein3.4.23.160.451
3lzv017Gag-Pol polyprotein3.4.23.160.451
3nls016Gag-Pol polyprotein3.4.23.160.451
3vf7031Gag-Pol polyprotein3.4.23.160.451
1bdrIM1Gag-Pol polyprotein3.4.23.160.450
1sduMK1Gag-Pol polyprotein3.4.23.160.450
3bva2NCGag-Pol polyprotein3.4.23.160.450
3ekv478Gag-Pol polyprotein3.4.23.160.450
3o9hK2EGag-Pol polyprotein/0.450
4hla017Gag-Pol polyprotein3.4.23.160.450
1k6tXN1Gag-Pol polyprotein3.4.23.160.449
2q54MU1Protease/0.449
7upjINUGag-Pol polyprotein3.4.23.160.449
1ajvNMBGag-Pol polyprotein3.4.23.160.448
1fff0Q4Gag-Pol polyprotein3.4.23.160.448
1k6pXN3Gag-Pol polyprotein3.4.23.160.448
2bpxMK1Gag-Pol polyprotein3.4.23.160.448
2p3c3TLProtease/0.448
2qhyMZ1Gag-Pol polyprotein/0.448
4dqe017Gag-Pol polyprotein/0.448
4dqh017Gag-Pol polyprotein/0.448
1bv9XV6Gag-Pol polyprotein3.4.23.160.447
1ebzBECGag-Pol polyprotein3.4.23.160.447
1mrxK57Gag-Pol polyprotein3.4.23.160.447
3bxrDRRGag-Pol polyprotein3.4.23.160.447
3nu5478Gag-Pol polyprotein3.4.23.160.447
3o9fK2DGag-Pol polyprotein/0.447
1a940Q4Gag-Pol polyprotein3.4.23.160.446
3mxdK53Gag-Pol polyprotein3.4.23.160.446
1ebk0Q4Gag-Pol polyprotein3.4.23.160.445
1m0b0ZQGag-Pol polyprotein3.4.23.160.445
2bbbHH1Gag-Pol polyprotein3.4.23.160.445
4njsG08Protease/0.445
2b60RITPol polyprotein/0.444
2i4dQFIProtease/0.444
1meuDMPGag-Pol polyprotein3.4.23.160.443
3nu3478Gag-Pol polyprotein3.4.23.160.443
1qbrXV6Gag-Pol polyprotein3.4.23.160.442
3lzu017Gag-Pol polyprotein3.4.23.160.442
3o9eA60Pol polyprotein/0.442
4dqf017Gag-Pol polyprotein/0.442
1metDMPGag-Pol polyprotein3.4.23.160.441
2r3wG3GGag-Pol polyprotein3.4.23.160.441
3nu6478Gag-Pol polyprotein3.4.23.160.441
1sivPSIGag-Pol polyprotein/0.440
3i6oGR6Gag-Pol polyprotein3.4.23.160.440
3o9aK14Pol polyprotein/0.440
3pwm017Gag-Pol polyprotein3.4.23.160.440
3qaaG04Gag-Pol polyprotein3.4.23.160.440