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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3kvxFMYMitogen-activated protein kinase 102.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3kvxFMYMitogen-activated protein kinase 102.7.11.241.000
2xrwANPMitogen-activated protein kinase 82.7.11.240.565
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.538
4j95ACPFibroblast growth factor receptor 2/0.485
3i60E86Mitogen-activated protein kinase 12.7.11.240.478
4qnyANPMitogen activated protein kinase, putative/0.473
1pmn984Mitogen-activated protein kinase 102.7.11.240.462
4ux9ANPMitogen-activated protein kinase 82.7.11.240.462
2xs0ANPMitogen-activated protein kinase 82.7.11.240.461
3orpAGSSerine/threonine protein kinase/0.460
1jnkANPMitogen-activated protein kinase 102.7.11.240.458
5dnrATPAurora kinase A2.7.11.10.458
4ocvANPAminoglycoside phosphotransferase/0.455
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.453
2j0lANPFocal adhesion kinase 12.7.10.20.443
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.443
4j99ACPFibroblast growth factor receptor 2/0.443
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.442
5e8ySTUTGF-beta receptor type-22.7.11.300.442
1i44ACPInsulin receptor2.7.10.10.441
3eljGS7Mitogen-activated protein kinase 82.7.11.240.440
3nieANPMitogen-activated protein kinase/0.440