scPDB - Distribution of Binding site Similarity values of 3kjs entry / Site 4

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	1.000
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.620
3eel	53T	Uncharacterized protein	/	0.583
3qlz	QLZ	Uncharacterized protein	/	0.579
4h98	14Q	Uncharacterized protein	/	0.572
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.570
3qlx	QLR	Uncharacterized protein	/	0.570
3eek	53S	Uncharacterized protein	/	0.568
3cse	N22	Uncharacterized protein	/	0.562
3eej	53R	Uncharacterized protein	/	0.560
3eem	53V	Uncharacterized protein	/	0.560
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.558
3qly	55V	Uncharacterized protein	/	0.549
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.548
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.548
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.542
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.541
2w3v	TOP	Dihydrofolate reductase	/	0.540
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.540
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.529
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.528
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.527
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.527
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.525
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.523
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.521
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.520
4p66	MTX	Dihydrofolate reductase	/	0.520
2zza	FOL	Dihydrofolate reductase	/	0.518
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.518
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.517
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.517
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.516
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.515
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.514
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.510
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.509
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.509
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.508
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.507
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.506
3ia4	MTX	Dihydrofolate reductase	/	0.505
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.505
3jwm	5WB	Dihydrofolate reductase	/	0.504
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.502
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.498
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.498
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.498
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.497
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.495
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.495
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.494
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.491
3sa2	7DR	Dihydrofolate reductase	/	0.491
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.490
4ele	31I	Dihydrofolate reductase	/	0.490
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.486
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.485
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.484
3jwc	EKB	Dihydrofolate reductase	/	0.483
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.482
3jw5	TOP	Dihydrofolate reductase	/	0.481
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.480
3fl8	RAR	Dihydrofolate reductase	/	0.480
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.480
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.479
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.478
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.478
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.474
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.472
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.471
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.470
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.470
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.469
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.469
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.468
3tqb	FOL	Dihydrofolate reductase	/	0.467
4elb	34R	Dihydrofolate reductase	/	0.467
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.467
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.467
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.466
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.465
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.464
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.461
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.461
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.461
2qd3	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.459
3tq9	MTX	Dihydrofolate reductase	/	0.458
3sa1	6DR	Dihydrofolate reductase	/	0.457
5hi6	MTX	Dihydrofolate reductase	/	0.457
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.455
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.452
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.452
3fra	I2H	Dihydrofolate reductase	1.5.1.3	0.451
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.451
4nb6	444	Nuclear receptor ROR-gamma	/	0.451
4nx6	FOL	Dihydrofolate reductase	1.5.1.3	0.451
1ia2	TQ4	Dihydrofolate reductase	1.5.1.3	0.449
2w3w	VG9	Dihydrofolate reductase	/	0.449
3dau	MTX	Dihydrofolate reductase	1.5.1.3	0.449
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.449
1rf7	DHF	Dihydrofolate reductase	1.5.1.3	0.448
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.448
3lu8	IQX	Serum albumin	/	0.448
4elb	34S	Dihydrofolate reductase	/	0.448
4r20	AER	Cytochrome P450 family 17 polypeptide 2	/	0.448
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.447
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.447
3fco	IIG	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.446
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.446
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.446
4fjz	4FJ	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.446
1ly4	COQ	Dihydrofolate reductase	1.5.1.3	0.445
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.445
4ej1	FOL	Dihydrofolate reductase	1.5.1.3	0.444
3fyw	XCF	Dihydrofolate reductase	1.5.1.3	0.443
3sh2	5DR	Dihydrofolate reductase	1.5.1.3	0.443
4elg	52J	Dihydrofolate reductase	/	0.443
4kjj	FOL	Dihydrofolate reductase	1.5.1.3	0.443
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.442
4j6c	STR	Cytochrome P450 monooxygenase	/	0.442
1m13	HYF	Nuclear receptor subfamily 1 group I member 2	/	0.441
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.441
4ia7	BIV	Vitamin D3 receptor A	/	0.441
2znq	401	Peroxisome proliferator-activated receptor delta	/	0.440
3rg9	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.440