sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3kjm | 245 | Cytokinin dehydrogenase 1 | 1.5.99.12 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3kjm | 245 | Cytokinin dehydrogenase 1 | 1.5.99.12 | 1.000 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.557 | |
| 1w1r | ZEA | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.484 | |
| 3s1c | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.472 | |
| 4o95 | 245 | Cytokinin dehydrogenase 4 | / | 0.470 | |
| 4djw | 0KP | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.457 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3syi | FAD | Sulfide-quinone reductase | / | 0.450 | |
| 4h3i | 10V | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 5hsa | FAS | Alcohol oxidase 1 | 1.1.3.13 | 0.450 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.449 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.449 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.448 | |
| 4l7j | 1W2 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.447 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.446 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.445 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.445 | |
| 1e1k | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.444 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 4isk | 1JY | Thymidylate synthase | / | 0.444 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.443 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.442 | |
| 4djy | 0KR | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4imp | NDP | Polyketide synthase extender modules 3-4 | / | 0.442 | |
| 2b9y | FAD | Putative aminooxidase | / | 0.441 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.441 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.440 | |
| 3zpu | M8B | Gag-Pol polyprotein | 3.4.23.16 | 0.440 |