sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3itz | P66 | Mitogen-activated protein kinase 14 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 1.000 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.618 | |
| 3fl4 | FL4 | Mitogen-activated protein kinase 14 | / | 0.589 | |
| 3rin | I2O | Mitogen-activated protein kinase 14 | / | 0.575 | |
| 3fko | FKO | Mitogen-activated protein kinase 14 | / | 0.569 | |
| 3fkn | FKN | Mitogen-activated protein kinase 14 | / | 0.568 | |
| 3e92 | G6A | Mitogen-activated protein kinase 14 | / | 0.566 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.564 | |
| 3fmm | XI2 | Mitogen-activated protein kinase 14 | / | 0.551 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.550 | |
| 1zzl | TZY | Mitogen-activated protein kinase 14 | / | 0.549 | |
| 3bx5 | 304 | Mitogen-activated protein kinase 14 | / | 0.546 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.545 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.544 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.537 | |
| 3gfe | P37 | Mitogen-activated protein kinase 14 | / | 0.520 | |
| 3pg3 | DG7 | Mitogen-activated protein kinase 14 | / | 0.518 | |
| 3u8w | 09J | Mitogen-activated protein kinase 14 | / | 0.506 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.504 | |
| 3uvq | FS8 | Mitogen-activated protein kinase 14 | / | 0.502 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.498 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.497 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.496 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.494 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.490 | |
| 2bal | PQA | Mitogen-activated protein kinase 14 | / | 0.489 | |
| 3fkl | FKL | Mitogen-activated protein kinase 14 | / | 0.488 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.488 | |
| 3c5u | P41 | Mitogen-activated protein kinase 14 | / | 0.479 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.477 | |
| 2yix | YIX | Mitogen-activated protein kinase 14 | / | 0.473 | |
| 3l8x | N4D | Mitogen-activated protein kinase 14 | / | 0.472 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.469 | |
| 4aac | AAV | Mitogen-activated protein kinase 14 | / | 0.469 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.468 | |
| 2rg6 | 287 | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 3b2w | 9NH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.463 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 2zb0 | GK3 | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 4aa4 | QC0 | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 1zyj | BI5 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3uib | SB2 | Putative mitogen-activated protein kinase | / | 0.451 | |
| 3dt1 | P40 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.448 | |
| 3fmn | 530 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.446 | |
| 3fln | 3FN | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3nww | 3NW | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.445 | |
| 4kip | 1R9 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.445 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.444 | |
| 1wbw | LI4 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.444 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.444 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3fly | FLY | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.443 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 3abi | NAD | Uncharacterized protein | / | 0.442 | |
| 3dtw | A96 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.442 | |
| 1di9 | MSQ | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.441 | |
| 3cp9 | C19 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.441 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.441 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1ouy | 094 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.440 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.440 |