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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.47

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.471.000
3iqhTYR_ASP_ILECysteine synthase2.5.1.470.670
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.596
3iqgASN_TRP_ASN_ILECysteine synthase2.5.1.470.506
1xe55FEPlasmepsin-23.4.23.390.463
3nsh957Beta-secretase 13.4.23.460.458
4i0i957Beta-secretase 13.4.23.460.458
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.456
3tjzGNPADP-ribosylation factor 1/0.455
3k5c0BIBeta-secretase 13.4.23.460.449
4xguADPPutative pachytene checkpoint protein 2/0.449
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.445
1rneC60Renin3.4.23.150.441
4egbNADdTDP-glucose 4,6-dehydratase/0.441