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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3i5zZ48Mitogen-activated protein kinase 12.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3i5zZ48Mitogen-activated protein kinase 12.7.11.241.000
4fv6E57Mitogen-activated protein kinase 12.7.11.240.577
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.552
3i60E86Mitogen-activated protein kinase 12.7.11.240.529
4qnyANPMitogen activated protein kinase, putative/0.482
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.464
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.462
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.457
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.455
3gu83GUDeath-associated protein kinase 12.7.11.10.449
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.446
1ig1ANPDeath-associated protein kinase 12.7.11.10.444
1qmzATPCyclin-dependent kinase 22.7.11.220.444
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.442