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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.31.000
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.587
1dg8NDPDihydrofolate reductase1.5.1.30.520
3tqaNDPDihydrofolate reductase/0.509
3qlsNDPDihydrofolate reductase1.5.1.30.507
2w3bNDPDihydrofolate reductase1.5.1.30.502
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.494
1j3kNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.476
3dg8NDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.473
4kl9NDPDihydrofolate reductase1.5.1.30.467
8dfrNDPDihydrofolate reductase1.5.1.30.462
1j3jNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.452
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447