sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3gki | CLR | Niemann-Pick C1 protein |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3gki | CLR | Niemann-Pick C1 protein | / | 1.000 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.711 | |
| 2rc6 | NAP | Ferredoxin--NADP reductase | / | 0.482 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.475 | |
| 3bhl | THG | Thymidylate synthase | / | 0.466 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.460 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.459 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.458 | |
| 1kzu | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.458 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.458 | |
| 2eix | FAD | NADH-cytochrome b5 reductase | / | 0.457 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.457 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.454 | |
| 1pt8 | ACO | Formyl-CoA:oxalate CoA-transferase | / | 0.453 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.452 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.450 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.450 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.449 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.448 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.447 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.446 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.445 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.442 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.441 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.441 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 3h1v | TK1 | Glucokinase | 2.7.1.2 | 0.440 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.440 |