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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3gep24HHypoxanthine-guanine phosphoribosyltransferase2.4.2.8

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3gep24HHypoxanthine-guanine phosphoribosyltransferase2.4.2.81.000
3ggj25HHypoxanthine-guanine phosphoribosyltransferase2.4.2.80.612
3ggcH26Hypoxanthine-guanine phosphoribosyltransferase2.4.2.80.599
1i5eU5PUracil phosphoribosyltransferase/0.482
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.460
1qk35GPHypoxanthine-guanine-xanthine phosphoribosyltransferase2.4.2.220.452
2vn0TDZCytochrome P450 2C8/0.452
4v2gITCTetracycline repressor protein class D/0.451
2yeiXQIHeat shock protein HSP 90-alpha/0.449
2jn3JN3Fatty acid-binding protein, liver/0.443
2oapANPType II secretion system protein (GspE-2)/0.443
4m83ERYOleandomycin glycosyltransferase2.4.10.442
3d8vUD1Bifunctional protein GlmU/0.441