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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3a9wNADNDP-sugar epimerase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3a9wNADNDP-sugar epimerase/1.000
3a1nNADNDP-sugar epimerase/0.668
3a4vNADNDP-sugar epimerase/0.637
3ajrNADNDP-sugar epimerase/0.631
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.493
5lc1NADL-threonine 3-dehydrogenase/0.489
3wmxNADNAD dependent epimerase/dehydratase/0.482
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.481
2wsbNADGalactitol dehydrogenase/0.477
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.455
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.454
2yy7NADL-threonine dehydrogenase/0.451
1zemNADXylitol dehydrogenase/0.450
1rkxNADCDP-D-glucose-4,6-dehydratase/0.449
2p5uNADUDP-glucose 4-epimerase/0.448
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.447
3wdsNADNADH-dependent quinuclidinone reductase/0.445
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.445
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.443
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.442
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.442
4gh5NADShort-chain dehydrogenase/reductase SDR/0.442
1b16NAQAlcohol dehydrogenase1.1.1.10.441
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.441
3ak4NADNADH-dependent quinuclidinone reductase/0.440