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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3a60STURibosomal protein S6 kinase beta-12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3a60STURibosomal protein S6 kinase beta-12.7.11.11.000
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.489
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.470
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.469
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.468
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.464
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.462
4bgg844Activin receptor type-12.7.11.300.461
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.460
3hmm855TGF-beta receptor type-12.7.11.300.459
4erwSTUCyclin-dependent kinase 22.7.11.220.459
4i22IREEpidermal growth factor receptor2.7.10.10.459
4jia1K3Tyrosine-protein kinase JAK2/0.459
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.457
4gmy0X5Tyrosine-protein kinase JAK2/0.456
4dymIYZActivin receptor type-12.7.11.300.455
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.454
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.454
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.454
1di8DTQCyclin-dependent kinase 22.7.11.220.452
1h1r6CPCyclin-dependent kinase 22.7.11.220.452
1g5sI17Cyclin-dependent kinase 22.7.11.220.451
3gubGUBDeath-associated protein kinase 12.7.11.10.451
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.451
2wotZZGTGF-beta receptor type-12.7.11.300.450
3ggfGVDSerine/threonine-protein kinase 26/0.450
3mtfA3FActivin receptor type-12.7.11.300.450
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.450
1aq1STUCyclin-dependent kinase 22.7.11.220.449
1ykr628Cyclin-dependent kinase 22.7.11.220.449
4qmpDKISerine/threonine-protein kinase 242.7.11.10.449
1gih1PUCyclin-dependent kinase 22.7.11.220.448
2hw2RFPRifampin ADP-ribosyl transferase/0.448
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.448
3rk909ZCyclin-dependent kinase 22.7.11.220.448
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.447
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.447
1vjy460TGF-beta receptor type-12.7.11.300.446
1xjdSTUProtein kinase C theta type2.7.11.130.446
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.446
2xa4AZ5Tyrosine-protein kinase JAK2/0.446
3rk708ZCyclin-dependent kinase 22.7.11.220.445
4hvh19RTyrosine-protein kinase JAK32.7.10.20.445
3gxlQIGTGF-beta receptor type-12.7.11.300.444
1h1s4SPCyclin-dependent kinase 22.7.11.220.443
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.443
2j0m4STFocal adhesion kinase 12.7.10.20.443
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.443
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.443
3zep1NXTyrosine-protein kinase JAK32.7.10.20.443
4bbe3O4Tyrosine-protein kinase JAK2/0.443
3a4pDFQHepatocyte growth factor receptor2.7.10.10.442
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.442
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.441
5hs1VORLanosterol 14-alpha demethylase/0.441
3a62STURibosomal protein S6 kinase beta-12.7.11.10.440