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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2zxbZXBAlpha-L-fucosidase, putative

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2zxbZXBAlpha-L-fucosidase, putative/1.000
2zx5ZX5Alpha-L-fucosidase, putative/0.788
2zx9ZX9Alpha-L-fucosidase, putative/0.785
2zx6ZX6Alpha-L-fucosidase, putative/0.686
2zx8ZX8Alpha-L-fucosidase, putative/0.596
2zx7ZX7Alpha-L-fucosidase, putative/0.591
1t1sCBQ1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.487
3n1s5GPPurine nucleoside phosphoramidase/0.485
5d4vYGPUncharacterized protein MJ0489/0.483
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.464
2vn1FK5Peptidylprolyl isomerase/0.461
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.458
2zjwREFCasein kinase II subunit alpha2.7.11.10.458
1zgaHMKIsoflavone 4'-O-methyltransferase/0.456
4h4sFADBiphenyl dioxygenase ferredoxin reductase subunit/0.454
1vi2NADQuinate/shikimate dehydrogenase/0.453
2g37FADProline dehydrogenase/0.452
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4h50FADBiphenyl dioxygenase ferredoxin reductase subunit/0.452
2e9zUTPGenome polyprotein/0.451
3hv4L51Mitogen-activated protein kinase 14/0.451
1ao8MTXDihydrofolate reductase1.5.1.30.450
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4bgbADPPredicted molecular chaperone distantly related to HSP70-fold metalloproteases/0.449
4qms1N1Serine/threonine-protein kinase 242.7.11.10.449
3wo1ADPAlanine--anticapsin ligase/0.448
3zm62GNUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.447
1kyzFERCaffeic acid 3-O-methyltransferase2.1.1.680.446
4oal245Cytokinin dehydrogenase 4/0.446
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1ove358Mitogen-activated protein kinase 14/0.445
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.445
2exlGDMEndoplasmin/0.444
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.443
2jedLG8Protein kinase C theta type2.7.11.130.442
3n6mGTPGenome polyprotein/0.442
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
2j7t274Serine/threonine-protein kinase 102.7.11.10.441
3tm0ANPAminoglycoside 3'-phosphotransferase2.7.1.950.441
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
1mabATPATP synthase subunit alpha, mitochondrial/0.440
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4jhz1KVBeta-glucuronidase3.2.1.310.440