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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2zitNADExotoxin A2.4.2.36

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2zitNADExotoxin A2.4.2.361.000
3b78NADExotoxin A2.4.2.360.735
3b82NADExotoxin A2.4.2.360.620
3b8hNADExotoxin A2.4.2.360.618
1zm4TADExotoxin A2.4.2.360.503
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.464
4bj9UHBTankyrase-22.4.2.300.460
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.459
5ds309LPoly [ADP-ribose] polymerase 12.4.2.300.446
4tkg09LTankyrase-22.4.2.300.445
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.441