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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2zetGTPRas-related protein Rab-27B

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2zetGTPRas-related protein Rab-27B/1.000
3e5hGNPRas-related protein Rab-28/0.604
1zbdGTPRas-related protein Rab-3A/0.585
2gilGTPRas-related protein Rab-6A/0.585
5dhaGNPGTP-binding nuclear protein Ran/0.580
3tklGTPRas-related protein Rab-1A/0.577
2ffqGSPRas-related protein Rab-6B/0.564
3lbnGNPGTPase HRas/0.563
3w3zGTPGTP-binding nuclear protein Ran/0.561
1yzqGNPRas-related protein Rab-6A/0.560
4dltGNPGTPase HRas/0.560
3lawGNPRas-related protein Rab-7a/0.557
1t91GTPRas-related protein Rab-7a/0.556
3nbzGTPGTP-binding nuclear protein Ran/0.556
3oiuGNPGTPase HRas/0.556
1xtsGTPGTP-binding protein Rheb/0.555
3v4fGNPGTPase HRas/0.555
4nyiGNPGTPase HRas/0.555
1ibrGNPGTP-binding nuclear protein Ran/0.554
1xtrGNPGTP-binding protein Rheb/0.553
3oesGNPGTPase RhebL1/0.553
3bc1GNPRas-related protein Rab-27A/0.551
3tsoGNPRas-related protein Rab-25/0.550
3ea5GDPGTP-binding nuclear protein Ran/0.548
3a6pGTPGTP-binding nuclear protein Ran/0.547
1vg8GNPRas-related protein Rab-7a/0.545
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.545
1zc4GNPRas-related protein Ral-A/0.543
3rabGNPRas-related protein Rab-3A/0.536
4o25GTPGTP-binding protein Rheb/0.535
4cymGCPRas-related protein Rab-32/0.534
1e96GTPRas-related C3 botulinum toxin substrate 1/0.531
4qxaGTPRas-related protein Rab-9A/0.531
4nyjGNPGTPase HRas/0.526
1kmqGNPTransforming protein RhoA/0.525
4lhwGNPRas-related protein Rab-8A/0.525
4k81GTPGTPase HRas/0.524
4rkfGNPRas-related protein Rab-3/0.522
1yhnGTPRas-related protein Rab-7a/0.521
1g17GNPRas-related protein SEC4/0.519
3ddcGNPGTPase HRas/0.519
1zc3GNPRas-related protein Ral-A/0.516
3kucGDPRas-related protein Rap-1A/0.515
1k5dGNPGTP-binding nuclear protein Ran/0.514
3bbpGTPRas-related protein Rab-6A/0.513
3i3sGNPGTPase HRas/0.508
5b2zGNPGTPase HRas/0.508
5jljGNPGTP-binding nuclear protein Ran/0.507
2c5lGTPGTPase HRas/0.506
3kz1GSPTransforming protein RhoA/0.503
4kvgGTPRas-related protein Rap-1A/0.501
4ol0GTPGTP-binding nuclear protein Ran/0.501
4dlwGNPGTPase HRas/0.500
2rgcGNPGTPase HRas/0.499
3a58GNPGTP-binding protein RHO1/0.499
1a2bGSPTransforming protein RhoA/0.498
3oivGNPGTPase HRas/0.498
2fe4GDPRas-related protein Rab-6B/0.497
3rs5GNPGTPase HRas/0.496
4mitGTPRho-related protein racC/0.493
2bkuGTPGTP-binding nuclear protein Ran/0.492
2clsGTPRho-related GTP-binding protein Rho6/0.492
3tnfGNPRas-related protein Rab-8A/0.491
3wyfGTPGTP-binding nuclear protein/0.490
2gcpGSPRho-related GTP-binding protein RhoC/0.487
2rgeGNPGTPase HRas/0.487
3eg5GNPCell division control protein 42 homolog/0.486
3lbhGNPGTPase HRas/0.483
1cxzGSPTransforming protein RhoA/0.482
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.482
3l8yGNPGTPase HRas/0.480
4dxaGSPRas-related protein Rap-1b/0.480
1oixGDPRas-related protein Rab-11A/0.479
1s1cGNPTransforming protein RhoA/0.478
4xoiGTPTransforming protein RhoA/0.477
1ow3GDPTransforming protein RhoA/0.476
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.476
4uj3GNPRas-related protein Rab-11A/0.476
1zd9GDPADP-ribosylation factor-like protein 8A/0.474
5c46GSPRas-related protein Rab-11A/0.473
2rgbGNPGTPase HRas/0.472
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.470
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.466
3kudGDPGTPase HRas/0.464
5hpyGDPTransforming protein RhoA/0.464
1lfdGNPGTPase HRas/0.463
3lbiGNPGTPase HRas/0.462
3qbtGNPRas-related protein Rab-8A/0.462
3rs0GNPGTPase HRas/0.461
4g0nGNPGTPase HRas/0.461
1m7bGTPRho-related GTP-binding protein RhoE/0.459
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.459
3pitGNPRas-related protein M-Ras/0.459
3th5GNPRas-related C3 botulinum toxin substrate 1/0.458
1u0hGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.455
3rs4GNPGTPase HRas/0.452
4ohxADPProtein clpf-1/0.452
3jzdNADMaleylacetate reductase/0.450
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.449
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.449
3rslGNPGTPase HRas/0.448
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.448
4dzzADPPlasmid partitioning protein ParF/0.448
1uadGNPRas-related protein Ral-A/0.447
3cphGDPRas-related protein SEC4/0.447
4dsoGSPGTPase KRas/0.447
4js0GNPCell division control protein 42 homolog/0.446
3c14GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.445
3x1zGNPRas-related protein Rap-1b/0.444
4qbfAP5Adenylate kinase/0.444
1vbiNADMalate/L-lactate dehydrogenase family protein/0.443
3kkoGNPRas-related protein M-Ras/0.442
3rs7GNPGTPase HRas/0.442
4uj5GNPRas-related protein Rab-11A/0.441
2ql6ADPNicotinamide riboside kinase 1/0.440
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.440
4dsnGCPGTPase KRas/0.440