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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.11.000
2xk730ESerine/threonine-protein kinase Nek22.7.11.10.558
4afeGGYSerine/threonine-protein kinase Nek22.7.11.10.544
2xnn430Serine/threonine-protein kinase Nek22.7.11.10.537
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.504
2xkdT3MSerine/threonine-protein kinase Nek22.7.11.10.504
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.498
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.495
4a4xJUPSerine/threonine-protein kinase Nek22.7.11.10.485
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.483
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.463
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.463
2xnpWCXSerine/threonine-protein kinase Nek22.7.11.10.454
5uviZMAAdenosine receptor A2a/0.454
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.453
2xk6EQHSerine/threonine-protein kinase Nek22.7.11.10.446
5ab7MLCNonspecific lipid-transfer protein, putative/0.446
5k2aZMAAdenosine receptor A2a/0.444
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.443
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.440
5k2cZMAAdenosine receptor A2a/0.440