sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2vhx | NAD | Alanine dehydrogenase | 1.4.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2vhx | NAD | Alanine dehydrogenase | 1.4.1.1 | 1.000 | |
| 2vhz | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.627 | |
| 2vhv | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.605 | |
| 2voj | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.545 | |
| 2vhw | NAI | Alanine dehydrogenase | 1.4.1.1 | 0.539 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.477 | |
| 4wlo | NAI | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.475 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.468 | |
| 4wlu | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.463 | |
| 4wlv | NAD | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.457 | |
| 4l4s | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.450 | |
| 5a1t | NAI | L-lactate dehydrogenase | / | 0.450 | |
| 1hyh | NAD | L-2-hydroxyisocaproate dehydrogenase | / | 0.447 | |
| 1pzg | A3D | Lactate dehydrogenase | / | 0.447 | |
| 1x7d | NAD | Putative ornithine cyclodeaminase | / | 0.447 | |
| 1ptj | SND | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.444 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.441 | |
| 5mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.441 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.440 |