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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2rr1W8RGenome polyprotein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2rr1W8RGenome polyprotein/1.000
2rs1W84Genome polyprotein/0.884
2rm2W43Genome polyprotein/0.830
2r04W71Genome polyprotein/0.777
1hrvSDZGenome polyprotein/0.689
2du8FADD-amino-acid oxidase1.4.3.30.461
5jscFADPutative acyl-CoA dehydrogenase/0.460
2uuvFADAlkyldihydroxyacetonephosphate synthase2.5.1.260.458
2wetFADTryptophan 5-halogenase/0.454
2e48FADD-amino-acid oxidase1.4.3.30.453
1kf6FADFumarate reductase flavoprotein subunit1.3.5.40.452
4jtqNAPAldo-keto reductase family 1 member C2/0.446
1ryiFADGlycine oxidase1.4.3.190.443
2cwfNDPDelta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase/0.442
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.441