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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2p1oNLAProtein TRANSPORT INHIBITOR RESPONSE 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2p1oNLAProtein TRANSPORT INHIBITOR RESPONSE 1/1.000
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.479
3c6o2S2Protein TRANSPORT INHIBITOR RESPONSE 1/0.463
3c6n2S8Protein TRANSPORT INHIBITOR RESPONSE 1/0.456
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
1jdzFMBPurine nucleoside phosphorylase/0.449
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.449
1rkpIBMcGMP-specific 3',5'-cyclic phosphodiesterase/0.448
1kquBR4Phospholipase A2, membrane associated/0.447
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.445
4b8zGDPGDP-L-fucose synthase1.1.1.2710.445
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
1dgfNDPCatalase1.11.1.60.440
1umcTDP2-oxoisovalerate dehydrogenase subunit alpha1.2.4.40.440
1umcTDP2-oxoisovalerate dehydrogenase subunit beta1.2.4.40.440
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440