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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2o8jSAHHistone-lysine N-methyltransferase EHMT2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2o8jSAHHistone-lysine N-methyltransferase EHMT2/1.000
5jinSAMHistone-lysine N-methyltransferase EHMT2/0.647
3mo0SAHHistone-lysine N-methyltransferase EHMT1/0.646
3fpdSAHHistone-lysine N-methyltransferase EHMT1/0.627
2igqSAHHistone-lysine N-methyltransferase EHMT1/0.607
5jhnSAMHistone-lysine N-methyltransferase EHMT2/0.605
5jj0SAMHistone-lysine N-methyltransferase EHMT2/0.570
3hnaSAHHistone-lysine N-methyltransferase EHMT1/0.559
2rfiSAHHistone-lysine N-methyltransferase EHMT1/0.518
5czySAMEukaryotic huntingtin interacting protein B/0.517
4ypeSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.507
3swcSAHHistone-lysine N-methyltransferase EHMT1/0.499
3kmtSAHHistone H3K27 methylase/0.479
4qenSAHHistone-lysine N-methyltransferase, H3 lysine-9 specific SUVH42.1.1.430.474
4j4nD44Peptidylprolyl isomerase/0.462
1s63778Protein farnesyltransferase subunit beta2.5.1.580.461
3cbpSFGHistone-lysine N-methyltransferase SETD72.1.1.430.461
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.461
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.461
3ooiSAMHistone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific2.1.1.430.460
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.459
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.458
1rneC60Renin3.4.23.150.454
2il2LIXRenin3.4.23.150.454
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.453
4ypaSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.453
1bim0QBRenin3.4.23.150.452
2g1r3IGRenin3.4.23.150.452
3ru0SFGHistone-lysine N-methyltransferase SMYD32.1.1.430.452
2ifaFMNUncharacterized protein/0.451
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.450
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.449
4nv10FXFormyl transferase/0.449
2g1o2IGRenin3.4.23.150.448
4ynmSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.448
1q23FUAChloramphenicol acetyltransferase2.3.1.280.446
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.446
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.445
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.445
2g1s4IGRenin3.4.23.150.443
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.442
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.442
4b68NAPL-ornithine N(5)-monooxygenase/0.442
4nv14TGFormyl transferase/0.442
4ynpSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.442
2bqzSAHN-lysine methyltransferase KMT5A/0.441
2g1n1IGRenin3.4.23.150.441
2hpvFMNFMN-dependent NADH-azoreductase1.70.441
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4bfzZVZPantothenate kinase2.7.1.330.441
2g247IGRenin3.4.23.150.440
2gv8NDPThiol-specific monooxygenase1.14.130.440