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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2np7NEAModification methylase TaqI2.1.1.72

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2np7NEAModification methylase TaqI2.1.1.721.000
2ih2NEAModification methylase TaqI2.1.1.720.597
1g38NEAModification methylase TaqI2.1.1.720.566
2ibtNEAModification methylase TaqI2.1.1.720.561
4gkvNADAlcohol dehydrogenase, propanol-preferring1.1.1.10.509
3qv2SAH5-cytosine DNA methyltransferase/0.485
4aa0AA0Mitogen-activated protein kinase 14/0.478
1sg9SAMRelease factor glutamine methyltransferase2.1.1.2970.470
3kq7KQ7Mitogen-activated protein kinase 14/0.469
5bp9SAHPutative methyltransferase protein/0.469
4z34ON7Lysophosphatidic acid receptor 1/0.465
2zb3NDPProstaglandin reductase 21.3.1.480.462
1h2bNAJNAD-dependent alcohol dehydrogenase/0.456
1nv8SAMRelease factor glutamine methyltransferase2.1.1.2970.456
5e72SAMN2, N2-dimethylguanosine tRNA methyltransferase/0.456
3g7jGTXGlutathione transferase GST1-4/0.455
4kvzSAHPtnL protein/0.454
3ttp017Gag-Pol polyprotein3.4.23.160.453
3own3OWRenin3.4.23.150.452
3s1sSAHRestriction endonuclease BpuSI/0.452
5f2kSAHUncharacterized protein/0.451
3cjqSAHRibosomal protein L11 methyltransferase2.1.10.450
2eg5SAH7-methylxanthosine synthase 1/0.449
3tvuB37Acetyl-CoA carboxylase/0.447
1nv9SAHRelease factor glutamine methyltransferase2.1.1.2970.446
3pt6SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.446
2jn3JN3Fatty acid-binding protein, liver/0.445
2po7CHDFerrochelatase, mitochondrial4.99.1.10.445
3egvSAHRibosomal protein L11 methyltransferase2.1.10.445
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.444
1hszNADAlcohol dehydrogenase 1B1.1.1.10.443
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.443
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.443
1skmSAHModification methylase HhaI2.1.1.370.442
1vq1SAMRelease factor glutamine methyltransferase2.1.1.2970.442
2cmvNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.442
3a2oKNJGag-Pol polyprotein3.4.23.160.442
4a6bQG8Gag-Pol polyprotein3.4.23.160.442
4x2qNADRetinal dehydrogenase 21.2.1.360.442
2zifSAMMethyltransferase/0.441
2zwvSAHProbable ribosomal RNA small subunit methyltransferase/0.441
3bgcLJHGag-Pol polyprotein3.4.23.160.441
4j55031Gag-Pol polyprotein3.4.23.160.441