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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.184

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1841.000
4j7xNAPSepiapterin reductase1.1.1.1530.497
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.489
4j7uNAPSepiapterin reductase1.1.1.1530.486
4hwkNAPSepiapterin reductase1.1.1.1530.475
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.473
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.467
1snyNAPLD36273p/0.465
4qecNAPElxO/0.465
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.464
1n5dNDPCarbonyl reductase [NADPH] 1/0.463
5idwNAPShort-chain dehydrogenase/reductase SDR/0.461
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.456
3f1kNAPUncharacterized oxidoreductase YciK10.455
3toxNAPPutative oxidoreductase/0.453
1xg5NAPDehydrogenase/reductase SDR family member 11/0.451
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.449
1ipeNDPTropinone reductase 21.1.1.2360.448
1ae1NAPTropinone reductase 1/0.447
3ai3NDPNADPH-sorbose reductase/0.447
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.445
3p19NDPPutative blue fluorescent protein/0.442