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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2gn8NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.115

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2gn8NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1151.000
1ipeNDPTropinone reductase 21.1.1.2360.485
1snyNAPLD36273p/0.469
4hwkNAPSepiapterin reductase1.1.1.1530.469
1ae1NAPTropinone reductase 1/0.467
4j7uNAPSepiapterin reductase1.1.1.1530.464
4j7xNAPSepiapterin reductase1.1.1.1530.460
5idwNAPShort-chain dehydrogenase/reductase SDR/0.460
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.458
1oaaNAPSepiapterin reductase1.1.1.1530.454
2bd0NAPSepiapterin reductase/0.454
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.453
4qecNAPElxO/0.453
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.452
1w4zNAPPutative ketoacyl reductase1.3.10.450
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.446
3sjuNDPKeto reductase/0.446
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.441
1wntNAPL-xylulose reductase1.1.1.100.441
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.441