Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2gfsPQBMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2gfsPQBMitogen-activated protein kinase 14/1.000
1w7h3IPMitogen-activated protein kinase 14/0.636
3itzP66Mitogen-activated protein kinase 14/0.633
3fkoFKOMitogen-activated protein kinase 14/0.627
3fl4FL4Mitogen-activated protein kinase 14/0.621
2zb1GK4Mitogen-activated protein kinase 14/0.589
3ds6A17Mitogen-activated protein kinase 14/0.584
3fknFKNMitogen-activated protein kinase 14/0.577
3bx5304Mitogen-activated protein kinase 14/0.568
3e92G6AMitogen-activated protein kinase 14/0.553
3pg3DG7Mitogen-activated protein kinase 14/0.528
3d7zGK5Mitogen-activated protein kinase 14/0.527
3hub469Mitogen-activated protein kinase 14/0.527
3zsh469Mitogen-activated protein kinase 14/0.523
2zb0GK3Mitogen-activated protein kinase 14/0.520
3fmmXI2Mitogen-activated protein kinase 14/0.520
3fskRO6Mitogen-activated protein kinase 14/0.515
1zzlTZYMitogen-activated protein kinase 14/0.503
1ove358Mitogen-activated protein kinase 14/0.502
3fklFKLMitogen-activated protein kinase 14/0.500
3rinI2OMitogen-activated protein kinase 14/0.497
3u8w09JMitogen-activated protein kinase 14/0.495
3gc9B45Mitogen-activated protein kinase 112.7.11.240.493
5k2bZMAAdenosine receptor A2a/0.485
3lfeZ84Mitogen-activated protein kinase 14/0.482
3l8xN4DMitogen-activated protein kinase 14/0.481
3gfeP37Mitogen-activated protein kinase 14/0.479
3bv2P38Mitogen-activated protein kinase 14/0.475
3flwFLWMitogen-activated protein kinase 14/0.475
3flyFLYMitogen-activated protein kinase 14/0.475
3s4qNK0Mitogen-activated protein kinase 14/0.473
5k2cZMAAdenosine receptor A2a/0.472
5uviZMAAdenosine receptor A2a/0.467
3iphG11Mitogen-activated protein kinase 14/0.466
2balPQAMitogen-activated protein kinase 14/0.465
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.465
4dhyS41Glucokinase2.7.1.20.464
5iu86DZAdenosine receptor A2a/0.463
2zazGK1Mitogen-activated protein kinase 14/0.462
5k2aZMAAdenosine receptor A2a/0.461
2yixYIXMitogen-activated protein kinase 14/0.460
3fsfFSSMitogen-activated protein kinase 14/0.459
3flzFLZMitogen-activated protein kinase 14/0.458
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.457
4l5b1UXDeoxycytidine kinase2.7.1.740.457
1ouy094Mitogen-activated protein kinase 14/0.456
3c5uP41Mitogen-activated protein kinase 14/0.456
1kzjCB3Thymidylate synthase/0.455
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.455
3fmlFMLMitogen-activated protein kinase 14/0.455
3uvqFS8Mitogen-activated protein kinase 14/0.455
1trgCB3Thymidylate synthase/0.454
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.454
3uibSB2Putative mitogen-activated protein kinase/0.453
2rg6287Mitogen-activated protein kinase 14/0.452
3fi4FI4Mitogen-activated protein kinase 14/0.452
4eh60ONMitogen-activated protein kinase 14/0.452
1wbwLI4Mitogen-activated protein kinase 14/0.451
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.451
2jn3JN3Fatty acid-binding protein, liver/0.451
3zoiM2WIsopenicillin N synthase1.21.3.10.451
1bk0ACVIsopenicillin N synthase1.21.3.10.450
3lfa1N1Mitogen-activated protein kinase 14/0.450
2bu9HFVIsopenicillin N synthase1.21.3.10.449
3hv3R49Mitogen-activated protein kinase 14/0.449
3mpt1GKMitogen-activated protein kinase 14/0.449
4bb3KKAIsopenicillin N synthase1.21.3.10.449
2c3qGTXGlutathione S-transferase theta-12.5.1.180.448
5iubCLRAdenosine receptor A2a/0.448
3vf60H6Glucokinase2.7.1.20.447
4tvbNADHomospermidine synthase2.5.1.440.447
4xqcNADHomospermidine synthase2.5.1.440.447
5k2dZMAAdenosine receptor A2a/0.447
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.446
2ym2NAPPhenylacetone monooxygenase1.14.13.920.445
2gtnLIEMitogen-activated protein kinase 14/0.444
3fmn530Mitogen-activated protein kinase 14/0.444
3mpaSB2Mitogen-activated protein kinase 14/0.444
3ol5SAWCamphor 5-monooxygenase1.14.15.10.444
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.444
3fmh533Mitogen-activated protein kinase 14/0.443
4plpNADHomospermidine synthase2.5.1.440.443
1qiqACCIsopenicillin N synthase1.21.3.10.442
2jb4A14Isopenicillin N synthase1.21.3.10.442
2pswCOAN-alpha-acetyltransferase 50/0.442
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.442
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.442
5jy1NADPutative short-chain dehydrogenase/reductase/0.442
3s41S41Glucokinase2.7.1.20.440