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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2fk8SAMHydroxymycolate synthase MmaA42.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2fk8SAMHydroxymycolate synthase MmaA42.1.11.000
3ha3SAHHydroxymycolate synthase MmaA42.1.10.617
3ha5SFGHydroxymycolate synthase MmaA42.1.10.561
3ha7B32Hydroxymycolate synthase MmaA42.1.10.549
3busSAHDemethylrebeccamycin-D-glucose O-methyltransferase/0.479
2eg5SAH7-methylxanthosine synthase 1/0.454
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
2iko7IGRenin3.4.23.150.448
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
2aotSAHHistamine N-methyltransferase2.1.1.80.444
3n0cFADFlavin-dependent thymidylate synthase2.1.1.1480.443
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.440