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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2fe4GDPRas-related protein Rab-6B

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2fe4GDPRas-related protein Rab-6B/1.000
3oesGNPGTPase RhebL1/0.564
2gilGTPRas-related protein Rab-6A/0.550
2ffqGSPRas-related protein Rab-6B/0.542
1zbdGTPRas-related protein Rab-3A/0.541
4qxaGTPRas-related protein Rab-9A/0.534
3e5hGNPRas-related protein Rab-28/0.526
1yzqGNPRas-related protein Rab-6A/0.525
3cphGDPRas-related protein SEC4/0.522
1t91GTPRas-related protein Rab-7a/0.518
3bbpGTPRas-related protein Rab-6A/0.517
3tsoGNPRas-related protein Rab-25/0.516
1vg8GNPRas-related protein Rab-7a/0.509
3mjhGTPRas-related protein Rab-5A/0.508
4o25GTPGTP-binding protein Rheb/0.492
1yhnGTPRas-related protein Rab-7a/0.491
1xtsGTPGTP-binding protein Rheb/0.486
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.486
4o2rGDPGTP-binding protein Rheb/0.486
3lawGNPRas-related protein Rab-7a/0.484
4tq9GDPGTPase KRas/0.483
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.480
4lhwGNPRas-related protein Rab-8A/0.480
1zd9GDPADP-ribosylation factor-like protein 8A/0.478
3kkoGNPRas-related protein M-Ras/0.478
5dhaGNPGTP-binding nuclear protein Ran/0.475
4cymGCPRas-related protein Rab-32/0.474
1lfdGNPGTPase HRas/0.473
1uadGNPRas-related protein Ral-A/0.473
3w3zGTPGTP-binding nuclear protein Ran/0.473
4uj3GNPRas-related protein Rab-11A/0.469
3qbtGNPRas-related protein Rab-8A/0.468
1n6lGTPRas-related protein Rab-5A/0.467
1oixGDPRas-related protein Rab-11A/0.467
4k81GTPGTPase HRas/0.467
2rggGNPGTPase HRas/0.466
3bc1GNPRas-related protein Rab-27A/0.465
3kkqGDPRas-related protein M-Ras/0.463
4hdqGNPRas-related protein Rap-1b/0.463
3oivGNPGTPase HRas/0.462
4ql3GDPGTPase KRas/0.462
1x1rGDPRas-related protein M-Ras/0.460
4q71FADBifunctional protein PutA/0.459
2rgeGNPGTPase HRas/0.458
3a6pGTPGTP-binding nuclear protein Ran/0.457
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.455
1e96GTPRas-related C3 botulinum toxin substrate 1/0.454
3nbzGTPGTP-binding nuclear protein Ran/0.454
3rabGNPRas-related protein Rab-3A/0.454
4q03GDPGTPase KRas/0.454
4uj5GNPRas-related protein Rab-11A/0.454
5c46GSPRas-related protein Rab-11A/0.454
1xtrGNPGTP-binding protein Rheb/0.453
2j83BATUlilysin3.4.240.453
4lpkGDPGTPase KRas/0.453
1yidATPTryptophan--tRNA ligase 26.1.1.20.452
4lucGDPGTPase KRas/0.452
4xvrGNPGTPase HRas/0.452
5jljGNPGTP-binding nuclear protein Ran/0.452
3ddcGNPGTPase HRas/0.451
3tgpGNPGTPase HRas/0.451
3pitGNPRas-related protein M-Ras/0.450
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.449
4epxGDPGTPase KRas/0.447
2c5lGTPGTPase HRas/0.446
4l8gGDPGTPase KRas/0.445
2fg5GNPRas-related protein Rab-31/0.444
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.443
4nbwNADShort-chain dehydrogenase/reductase SDR/0.443
4xvqGNPGTPase HRas/0.442
3lbnGNPGTPase HRas/0.441
3tjzGNPADP-ribosylation factor 1/0.441
4obeGDPGTPase KRas/0.441