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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2cleF6FTryptophan synthase alpha chain

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2cleF6FTryptophan synthase alpha chain/1.000
2clfF6FTryptophan synthase alpha chain/0.681
4y6gF6FTryptophan synthase alpha chain/0.593
4wx2F6FTryptophan synthase alpha chain/0.585
4wx2F6FTryptophan synthase beta chain4.2.1.200.585
1k8zIAGTryptophan synthase alpha chain/0.575
4zqcF6FTryptophan synthase alpha chain/0.538
1qoqIGPTryptophan synthase alpha chain/0.498
1k7fIAVTryptophan synthase alpha chain/0.495
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.453
3h3sH15Collagen type IV alpha-3-binding protein/0.451
3pm1ETHTH-type transcriptional regulator QacR/0.451
3arvSAUChitinase A/0.447
4rh10TTSpore photoproduct lyase/0.446
5dp2NAPCurF/0.446
3slkNDPPolyketide synthase extender module 2/0.445
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1kzjCB3Thymidylate synthase/0.443
2ed3SAHDiphthine synthase/0.443
3g70A5TRenin3.4.23.150.442
2vbdV10Isopenicillin N synthase1.21.3.10.440