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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ceoT44Thyroxine-binding globulin

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ceoT44Thyroxine-binding globulin/1.000
4x30T44Thyroxine-binding globulin/0.524
3k5uPFQAurora kinase A2.7.11.10.469
3mdvCL6Cholesterol 24-hydroxylase/0.466
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.463
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.463
2panFADGlyoxylate carboligase4.1.1.470.462
1d7yFADFerredoxin reductase/0.459
2ovhAS0Progesterone receptor/0.459
3v9v21LPeroxisome proliferator-activated receptor gamma/0.458
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
1adfTADAlcohol dehydrogenase E chain1.1.1.10.456
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
3bv3P39Mitogen-activated protein kinase 14/0.456
2ie0ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
2vn0TDZCytochrome P450 2C8/0.454
4nmdFDABifunctional protein PutA/0.454
4q73FADBifunctional protein PutA/0.454
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.452
1e3eNAIAlcohol dehydrogenase 41.1.1.10.450
3mnrSD1Heat shock protein HSP 90-alpha/0.450
3stw2TDMethylketone synthase I/0.450
3g6wGTPUracil phosphoribosyltransferase2.4.2.90.449
4e5yNDPGDP-L-fucose synthase1.1.1.2710.448
4y93746Tyrosine-protein kinase/0.447
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
2zkjADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.446
3vt7VDXVitamin D3 receptor/0.446
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
2c7xNRBCytochrome P450 monooxygenase PikC/0.445
2d8aNADL-threonine 3-dehydrogenase/0.445
2fzwNADAlcohol dehydrogenase class-31.1.1.10.445
3mdmFJZCholesterol 24-hydroxylase/0.445
1gleADPGlycerol kinase/0.444
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.444
3cukFADD-amino-acid oxidase1.4.3.30.444
4ic7ANPMitogen-activated protein kinase 72.7.11.240.444
1j7kATPHolliday junction ATP-dependent DNA helicase RuvB/0.443
2p9cNAID-3-phosphoglycerate dehydrogenase1.1.1.950.443
3stxBKAMethylketone synthase I/0.443
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.443
2ejvNADL-threonine 3-dehydrogenase/0.442
2qk8MTXDihydrofolate reductase/0.442
2w1fL0FAurora kinase A2.7.11.10.442
4qe6JN3Bile acid receptor/0.442
4yntFDAGlucose oxidase, putative/0.442
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.441
3zuxTCHTransporter/0.441
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.440
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.440
3ii43IIDihydrolipoyl dehydrogenase1.8.1.40.440
4ivoACJProtoporphyrinogen oxidase1.3.3.40.440