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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2c5lGTPGTPase HRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2c5lGTPGTPase HRas/1.000
3v4fGNPGTPase HRas/0.661
2rgcGNPGTPase HRas/0.658
3pitGNPRas-related protein M-Ras/0.651
4k81GTPGTPase HRas/0.649
3oivGNPGTPase HRas/0.646
2rgbGNPGTPase HRas/0.639
2rgeGNPGTPase HRas/0.638
3kkoGNPRas-related protein M-Ras/0.631
3oiwGNPGTPase HRas/0.629
3ddcGNPGTPase HRas/0.623
4nyjGNPGTPase HRas/0.621
4dlxGNPGTPase HRas/0.616
3rs5GNPGTPase HRas/0.615
3l8yGNPGTPase HRas/0.612
4dltGNPGTPase HRas/0.612
4nyiGNPGTPase HRas/0.612
4hdoGNPRas-related protein Rap-1b/0.609
3lbnGNPGTPase HRas/0.606
4dlwGNPGTPase HRas/0.606
4dsnGCPGTPase KRas/0.603
1t91GTPRas-related protein Rab-7a/0.601
3i3sGNPGTPase HRas/0.601
3lbhGNPGTPase HRas/0.601
4g0nGNPGTPase HRas/0.600
3oiuGNPGTPase HRas/0.599
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.597
3lbiGNPGTPase HRas/0.595
4dlzGNPGTPase HRas/0.595
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.594
3rs0GNPGTPase HRas/0.593
3rs4GNPGTPase HRas/0.593
1e96GTPRas-related C3 botulinum toxin substrate 1/0.592
1zc4GNPRas-related protein Ral-A/0.592
3e5hGNPRas-related protein Rab-28/0.592
4dlvGNPGTPase HRas/0.590
3k8yGNPGTPase HRas/0.589
3oesGNPGTPase RhebL1/0.588
3rabGNPRas-related protein Rab-3A/0.588
3x1zGNPRas-related protein Rap-1b/0.587
5b2zGNPGTPase HRas/0.587
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.586
1zc3GNPRas-related protein Ral-A/0.585
2zetGTPRas-related protein Rab-27B/0.584
3rslGNPGTPase HRas/0.584
4kvgGTPRas-related protein Rap-1A/0.584
3kucGDPRas-related protein Rap-1A/0.583
4mitGTPRho-related protein racC/0.582
1kmqGNPTransforming protein RhoA/0.581
4hdqGNPRas-related protein Rap-1b/0.581
3rs7GNPGTPase HRas/0.580
3kudGDPGTPase HRas/0.578
4lhwGNPRas-related protein Rab-8A/0.578
1m7bGTPRho-related GTP-binding protein RhoE/0.577
1s1cGNPTransforming protein RhoA/0.575
3bbpGTPRas-related protein Rab-6A/0.575
1xtsGTPGTP-binding protein Rheb/0.572
1yhnGTPRas-related protein Rab-7a/0.572
4dlsGNPGTPase HRas/0.572
4xvrGNPGTPase HRas/0.572
5dhaGNPGTP-binding nuclear protein Ran/0.569
1zbdGTPRas-related protein Rab-3A/0.567
3a58GNPGTP-binding protein RHO1/0.566
1xtrGNPGTP-binding protein Rheb/0.564
2fe4GDPRas-related protein Rab-6B/0.563
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.560
1cxzGSPTransforming protein RhoA/0.559
3w3zGTPGTP-binding nuclear protein Ran/0.559
1yzqGNPRas-related protein Rab-6A/0.558
3eg5GNPCell division control protein 42 homolog/0.558
3a6pGTPGTP-binding nuclear protein Ran/0.556
4l9wGNPGTPase HRas/0.554
5jljGNPGTP-binding nuclear protein Ran/0.554
4o25GTPGTP-binding protein Rheb/0.553
1g17GNPRas-related protein SEC4/0.549
1vg8GNPRas-related protein Rab-7a/0.549
3nbzGTPGTP-binding nuclear protein Ran/0.548
5difGNPGTP-binding nuclear protein Ran/0.548
4rkfGNPRas-related protein Rab-3/0.546
1ibrGNPGTP-binding nuclear protein Ran/0.545
2gcpGSPRho-related GTP-binding protein RhoC/0.545
2gilGTPRas-related protein Rab-6A/0.545
3lawGNPRas-related protein Rab-7a/0.545
3tklGTPRas-related protein Rab-1A/0.545
3tsoGNPRas-related protein Rab-25/0.540
4xvqGNPGTPase HRas/0.539
1a2bGSPTransforming protein RhoA/0.538
4js0GNPCell division control protein 42 homolog/0.538
4ol0GTPGTP-binding nuclear protein Ran/0.536
4tq9GDPGTPase KRas/0.534
3wyfGTPGTP-binding nuclear protein/0.532
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.531
3ea5GDPGTP-binding nuclear protein Ran/0.530
1gwnGTPRho-related GTP-binding protein RhoE/0.529
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.528
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.528
3kkqGDPRas-related protein M-Ras/0.528
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.526
3kz1GSPTransforming protein RhoA/0.526
3tgpGNPGTPase HRas/0.526
4dsoGSPGTPase KRas/0.525
2ffqGSPRas-related protein Rab-6B/0.523
3cphGDPRas-related protein SEC4/0.521
3tnfGNPRas-related protein Rab-8A/0.521
4epxGDPGTPase KRas/0.521
1uadGNPRas-related protein Ral-A/0.519
2clsGTPRho-related GTP-binding protein Rho6/0.519
4l9sGDPGTPase HRas/0.519
4l8gGDPGTPase KRas/0.518
4qxaGTPRas-related protein Rab-9A/0.518
3k9lGNPGTPase HRas/0.517
4cymGCPRas-related protein Rab-32/0.513
1lfdGNPGTPase HRas/0.512
2rggGNPGTPase HRas/0.512
4dxaGSPRas-related protein Rap-1b/0.512
4lucGDPGTPase KRas/0.512
4ql3GDPGTPase KRas/0.512
3mjhGTPRas-related protein Rab-5A/0.511
3th5GNPRas-related C3 botulinum toxin substrate 1/0.510
2bkuGTPGTP-binding nuclear protein Ran/0.508
4o2lGTPGTP-binding protein Rheb/0.508
4lpkGDPGTPase KRas/0.507
4q03GDPGTPase KRas/0.507
1oixGDPRas-related protein Rab-11A/0.506
1yu9GNPRas-related protein Rab-4A/0.505
4obeGDPGTPase KRas/0.505
1zd9GDPADP-ribosylation factor-like protein 8A/0.499
1k5dGNPGTP-binding nuclear protein Ran/0.498
4ldjGDPGTPase KRas/0.497
2ce2GDPGTPase HRas/0.496
4q02GDPGTPase KRas/0.496
4lv6GDPGTPase KRas/0.495
3bc1GNPRas-related protein Rab-27A/0.493
4xoiGTPTransforming protein RhoA/0.491
4uj5GNPRas-related protein Rab-11A/0.489
5hpyGDPTransforming protein RhoA/0.489
3qbtGNPRas-related protein Rab-8A/0.486
1n6lGTPRas-related protein Rab-5A/0.483
2fg5GNPRas-related protein Rab-31/0.483
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.482
4dsuGDPGTPase KRas/0.480
5c46GSPRas-related protein Rab-11A/0.480
1d5cGDPGTPase (Rab6)/0.479
1z0aGDPRas-related protein Rab-2A/0.479
4wa7GDPGTPase KRas/0.478
4gzmGSPRas-related C3 botulinum toxin substrate 1/0.477
1x1rGDPRas-related protein M-Ras/0.476
2msdGNPMHC class I alpha chain/0.473
4uj3GNPRas-related protein Rab-11A/0.471
2cl6CAGGTPase HRas/0.469
1z2cGNPRho-related GTP-binding protein RhoC/0.468
4epwGDPGTPase KRas/0.468
3x1wGDPRas-related protein Rap-1b/0.466
3c14GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.464
5c1mCLRMu-type opioid receptor/0.463
1tu3GNPRas-related protein Rab-5A/0.462
4cidANPEH domain-containing protein 2/0.461
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.460
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.460
4d0lGSPRas-related protein Rab-11A/0.460
4o2rGDPGTP-binding protein Rheb/0.460
1culGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.458
1z2aGDPRas-related protein Rab-23/0.457
2q3fGNPRas-related GTP-binding protein D/0.456
1m2oGNPSmall COPII coat GTPase SAR13.6.50.455
2ic5GNPRas-related C3 botulinum toxin substrate 3/0.454
2bmeGNPRas-related protein Rab-4A/0.452
4lrwGDPGTPase KRas/0.449
2mseGNPMHC class I alpha chain/0.445
4dvgGSPRho family GTPase/0.445
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.444
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.444
1x1aSAMC-20 methyltransferase/0.442
3c14FOKAdenylate cyclase type 2/0.442
3c14FOKAdenylate cyclase type 5/0.442
3t1tGDPProbable gliding protein mglA/0.442
4paoGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.442
3w0aDS5Vitamin D3 receptor/0.440