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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2c0tL3GTyrosine-protein kinase HCK2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2c0tL3GTyrosine-protein kinase HCK2.7.10.21.000
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.727
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.598
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.547
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.543
3vs1VSATyrosine-protein kinase HCK2.7.10.20.543
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.533
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.520
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.517
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.506
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.500
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.499
3vryB43Tyrosine-protein kinase HCK2.7.10.20.494
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.491
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.485
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.479
3w2rW2REpidermal growth factor receptor2.7.10.10.468
3vs3VSETyrosine-protein kinase HCK2.7.10.20.459
4id71G0Activated CDC42 kinase 1/0.456
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.454
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.451
3h0aD30Peroxisome proliferator-activated receptor gamma/0.449
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
3w33W19Epidermal growth factor receptor2.7.10.10.444
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
2c6eHPMAurora kinase A2.7.11.10.441
4ih8B43Calmodulin-domain protein kinase 1/0.440