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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.91.000
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.598
2b378PSEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.581
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.580
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.578
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.577
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.574
4u0k744Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.553
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.535
2b35TCLEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.528
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.516
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.505
3fnfJPMEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.501
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.500
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.492
3abaFLICytochrome P450/0.490
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.490
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.483
1fmlRTLRetinol dehydratase/0.473
1fmjRTLRetinol dehydratase/0.470
1qxlFR8Adenosine deaminase3.5.4.40.469
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.464
5coqTCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
4j6bPLOCytochrome P450 monooxygenase/0.460
1umlFR4Adenosine deaminase3.5.4.40.457
1zsnTN2Enoyl-ACP reductase/0.455
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.455
4jbtASDCytochrome P450 monooxygenase/0.453
3iw8HIZMitogen-activated protein kinase 14/0.451
2dvlFADAcyl-CoA dehydrogenase/0.449
4jx1CAMCamphor 5-monooxygenase1.14.15.10.449
1zg32HIIsoflavone 4'-O-methyltransferase/0.447
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.447
4o701QKBromodomain-containing protein 4/0.447
1x8lOXRRetinol dehydratase/0.446
1jioDEB6-deoxyerythronolide B hydroxylase/0.444
1o5rFR9Adenosine deaminase3.5.4.40.444
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.443
4eevL1XHepatocyte growth factor receptor2.7.10.10.443
4r20AERCytochrome P450 family 17 polypeptide 2/0.442
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1jutLYDThymidylate synthase/0.440