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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1xqcAEJEstrogen receptor

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1xqcAEJEstrogen receptor/1.000
1uomPTIEstrogen receptor/0.542
1sj0E4DEstrogen receptor/0.532
1errRALEstrogen receptor/0.529
1yinCM3Estrogen receptor/0.527
1xp6AIUEstrogen receptor/0.525
1ndeMONEstrogen receptor beta/0.485
2jf9OHTEstrogen receptor/0.471
3abaFLICytochrome P450/0.470
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.467
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.466
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.461
4r21STRCytochrome P450 family 17 polypeptide 2/0.461
2nu9COASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.459
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.449
3qm4PN0Cytochrome P450 2D6/0.448
3t8xT8XT-cell surface glycoprotein CD1b/0.446
1o5rFR9Adenosine deaminase3.5.4.40.445
1qknRALEstrogen receptor beta/0.445
3reyXACAdenosine receptor A2a/0.445
1bveDMPGag-Pol polyprotein3.4.23.160.443
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.443
2p7zOHTEstrogen-related receptor gamma/0.442
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.442
4r20AERCytochrome P450 family 17 polypeptide 2/0.442