sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1xdk | REA | Retinoic acid receptor beta |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1xdk | REA | Retinoic acid receptor beta | / | 1.000 | |
| 4dm8 | REA | Retinoic acid receptor beta | / | 0.606 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.576 | |
| 1exa | 394 | Retinoic acid receptor gamma | / | 0.574 | |
| 1fd0 | 254 | Retinoic acid receptor gamma | / | 0.570 | |
| 1fcx | 184 | Retinoic acid receptor gamma | / | 0.560 | |
| 1fcy | 564 | Retinoic acid receptor gamma | / | 0.556 | |
| 2lbd | REA | Retinoic acid receptor gamma | / | 0.539 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.504 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.489 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.471 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.466 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.460 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.460 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.459 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.459 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.457 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.456 | |
| 2qjy | SMA | Cytochrome b | / | 0.456 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.456 | |
| 3cxh | SMA | Cytochrome b | / | 0.455 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.455 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.453 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.452 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.452 | |
| 3tfy | COA | N-alpha-acetyltransferase 50 | 2.3.1 | 0.451 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.449 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.449 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.449 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.449 | |
| 3nal | DBK | Calcium-transporting ATPase | / | 0.449 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.449 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.448 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.448 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.447 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.447 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 3aba | FLI | Cytochrome P450 | / | 0.445 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.444 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.444 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.443 | |
| 4mfb | 29T | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 3up3 | XCA | aceDAF-12 | / | 0.442 | |
| 1ezf | IN0 | Squalene synthase | 2.5.1.21 | 0.441 | |
| 2a4n | COA | Aac(6')-Ii protein | / | 0.441 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.440 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.440 |