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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1x28PGUAspartate aminotransferase2.6.1.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1x28PGUAspartate aminotransferase2.6.1.11.000
1ahgTYR_PLPAspartate aminotransferase2.6.1.10.614
1argPPDAspartate aminotransferase2.6.1.10.588
4rkdKETAminotransferase/0.588
1oxoIK2Aspartate aminotransferase, mitochondrial2.6.1.10.568
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.559
1cq8PY6Aspartate aminotransferase2.6.1.10.546
1arhPPDAspartate aminotransferase2.6.1.10.545
3qpg3QPAspartate aminotransferase2.6.1.10.543
1cq7PY5Aspartate aminotransferase2.6.1.10.538
1cq6PY4Aspartate aminotransferase2.6.1.10.531
4dbc3QPAspartate aminotransferase2.6.1.10.527
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.516
1maqPGUAspartate aminotransferase, mitochondrial2.6.1.10.516
1ivrCBAAspartate aminotransferase, mitochondrial2.6.1.10.510
4emyPLPAminotransferase class I and II/0.499
1akaPLPAspartate aminotransferase, mitochondrial2.6.1.10.498
4w5kPLPAspartate aminotransferase, mitochondrial/0.496
1ascNPLAspartate aminotransferase2.6.1.10.489
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.482
1toiHCIAspartate aminotransferase2.6.1.10.481
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.475
1tojHCIAspartate aminotransferase2.6.1.10.472
1mapKETAspartate aminotransferase, mitochondrial2.6.1.10.471
4fl0PLPAminotransferase ALD1, chloroplastic2.6.10.471
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.470
1yw8A75Methionine aminopeptidase 2/0.469
1rftPXMPyridoxal kinase2.7.1.350.467
2ay5IOPAromatic-amino-acid aminotransferase2.6.1.570.463
4bfuZVUPantothenate kinase2.7.1.330.462
1diaL24C-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.459
3ei8PL5LL-diaminopimelate aminotransferase, chloroplastic/0.459
4aoaIK2Beta-phenylalanine transaminase2.6.10.458
2e94364Geranylgeranyl pyrophosphate synthase/0.455
4jeyPLPAcetylornithine/succinyldiaminopimelate aminotransferase2.6.1.110.455
3e6eDCSAlanine racemase/0.454
1ppjANYCytochrome b/0.453
1w19T5P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.453
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.453
3fr5I4AFatty acid-binding protein, adipocyte/0.453
3aezGDPPantothenate kinase2.7.1.330.452
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.452
4je5PLPAromatic/aminoadipate aminotransferase 12.6.1.390.451
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.450
4a83DXCMajor pollen allergen Bet v 1-A/0.450
2c20NADUDP-glucose 4-epimerase/0.449
3elePLPAminotransferase/0.448
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.448
4lutDCSAlanine racemase/0.448
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.447
2rlcCHDCholoylglycine hydrolase3.5.1.240.447
2zsaADPPantothenate kinase2.7.1.330.447
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
1c7oPPGHemolysin/0.446
3arpDEQChitinase A/0.446
4wljIK2Kynurenine--oxoglutarate transaminase 12.6.1.70.446
3q43D66M1 family aminopeptidase3.4.110.444
1psa0ZLPepsin A3.4.23.10.443
3dr7GPDGDP-perosamine synthase/0.443
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3frkTQPQdtB/0.443
4xbjIN5Alanine racemase, biosynthetic/0.443
1pl6572Sorbitol dehydrogenase1.1.1.140.442
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.442
3h3t16HCollagen type IV alpha-3-binding protein/0.442
2a0wDIHPurine nucleoside phosphorylase2.4.2.10.441
2a84ATPPantothenate synthetase6.3.2.10.441
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.441
2ay2CXPAromatic-amino-acid aminotransferase2.6.1.570.440
3br3ETHTH-type transcriptional regulator QacR/0.440