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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1vq1SAMRelease factor glutamine methyltransferase2.1.1.297

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1vq1SAMRelease factor glutamine methyltransferase2.1.1.2971.000
1nv9SAHRelease factor glutamine methyltransferase2.1.1.2970.611
1nv8SAMRelease factor glutamine methyltransferase2.1.1.2970.537
1sg9SAMRelease factor glutamine methyltransferase2.1.1.2970.521
3q87SAMN6 ADENINE SPECIFIC DNA METHYLASE (METHYLTRANSFERASE SUPERFAMILY)/0.466
2zzmSAMtRNA (guanine(37)-N1)-methyltransferase Trm5b2.1.1.2280.448