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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1vcfFMNIsopentenyl-diphosphate delta-isomerase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1vcfFMNIsopentenyl-diphosphate delta-isomerase/1.000
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.497
1xddAAYIntegrin alpha-L/0.473
4a2aATPCell division protein FtsA/0.464
1w6hTITPlasmepsin-23.4.23.390.460
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.460
1juvNDPDihydrofolate reductase1.5.1.30.459
3keuATPPyridoxal kinase2.7.1.350.457
2zrxFMNIsopentenyl-diphosphate delta-isomerase/0.451
3uoyFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.451
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.449
2zrvFNRIsopentenyl-diphosphate delta-isomerase/0.447
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.446
3kb1ADPIron-sulfur cluster carrier protein/0.445
1lbcCYZGlutamate receptor 2/0.444
1lf2R37Plasmepsin-23.4.23.390.444
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
1me6IVSPlasmepsin-23.4.23.390.443
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.443
3b70NAPEnoyl reductase LovC10.443
3in6FMNUncharacterized protein/0.443
3ha7B32Hydroxymycolate synthase MmaA42.1.10.442
3jynNDPQuinone oxidoreductase/0.442
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4yaoFMNNADPH--cytochrome P450 reductase/0.442
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.441
3slkNDPPolyketide synthase extender module 2/0.441
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.441
4y8vADPAcyl-CoA synthetase (NDP forming)/0.441
4z24FADPutative GMC-type oxidoreductase R13510.441
1rneC60Renin3.4.23.150.440
2trtTACTetracycline repressor protein class D/0.440
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3gqvNAPEnoyl reductase LovC10.440