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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1uxpNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1uxpNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/1.000
1uxvNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.786
1uxrNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.559
1ky8NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.547
2jg7NADAntiquitin/0.527
3rhjNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.511
2j6lNAIAlpha-aminoadipic semialdehyde dehydrogenase1.2.1.310.505
4pxnNADAldehyde dehydrogenase family 7 member B4/0.490
3hazNADBifunctional protein PutA/0.489
3lnsNAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.483
1a4zNADAldehyde dehydrogenase, mitochondrial1.2.1.30.475
2id2NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase1.2.1.90.471
3rhlNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.465
3rhqNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.465
1ie8KH1Vitamin D3 receptor/0.456
1o6rR19Squalene--hopene cyclase4.2.1.1290.456
4i8pNADAminoaldehyde dehydrogenase 1/0.455
5kf2ACOPredicted acetyltransferase/0.455
1t90NADMalonate-semialdehyde dehydrogenase1.2.1.270.452
1h36R88Squalene--hopene cyclase4.2.1.1290.444
4iteTEYVitamin D3 receptor/0.443
1o6qR17Squalene--hopene cyclase4.2.1.1290.440
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.440
5kgjACOPredicted acetyltransferase/0.440