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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1t91GTPRas-related protein Rab-7a

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1t91GTPRas-related protein Rab-7a/1.000
1yzqGNPRas-related protein Rab-6A/0.638
2gilGTPRas-related protein Rab-6A/0.627
1vg8GNPRas-related protein Rab-7a/0.612
3e5hGNPRas-related protein Rab-28/0.612
2ffqGSPRas-related protein Rab-6B/0.599
3bbpGTPRas-related protein Rab-6A/0.589
1yhnGTPRas-related protein Rab-7a/0.587
1zbdGTPRas-related protein Rab-3A/0.586
2fe4GDPRas-related protein Rab-6B/0.580
3lawGNPRas-related protein Rab-7a/0.573
3oesGNPGTPase RhebL1/0.571
4qxaGTPRas-related protein Rab-9A/0.568
4o25GTPGTP-binding protein Rheb/0.557
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.555
3w3zGTPGTP-binding nuclear protein Ran/0.551
1xtsGTPGTP-binding protein Rheb/0.547
3lbnGNPGTPase HRas/0.543
4cymGCPRas-related protein Rab-32/0.542
3ea5GDPGTP-binding nuclear protein Ran/0.541
5jljGNPGTP-binding nuclear protein Ran/0.541
2zetGTPRas-related protein Rab-27B/0.540
5dhaGNPGTP-binding nuclear protein Ran/0.535
3a6pGTPGTP-binding nuclear protein Ran/0.533
4lhwGNPRas-related protein Rab-8A/0.533
3bc1GNPRas-related protein Rab-27A/0.531
1e96GTPRas-related C3 botulinum toxin substrate 1/0.527
4rkfGNPRas-related protein Rab-3/0.527
3nbzGTPGTP-binding nuclear protein Ran/0.522
1xtrGNPGTP-binding protein Rheb/0.521
3oiwGNPGTPase HRas/0.519
3tsoGNPRas-related protein Rab-25/0.518
3l8yGNPGTPase HRas/0.517
2c5lGTPGTPase HRas/0.515
3v4fGNPGTPase HRas/0.515
1g17GNPRas-related protein SEC4/0.512
2rgeGNPGTPase HRas/0.512
3a58GNPGTP-binding protein RHO1/0.510
3rabGNPRas-related protein Rab-3A/0.509
4dlwGNPGTPase HRas/0.508
5difGNPGTP-binding nuclear protein Ran/0.508
3i3sGNPGTPase HRas/0.507
4k81GTPGTPase HRas/0.507
4nyjGNPGTPase HRas/0.506
4g0nGNPGTPase HRas/0.505
4dltGNPGTPase HRas/0.503
3ddcGNPGTPase HRas/0.502
4ol0GTPGTP-binding nuclear protein Ran/0.501
3rs5GNPGTPase HRas/0.499
5b2zGNPGTPase HRas/0.496
2bkuGTPGTP-binding nuclear protein Ran/0.495
4hdoGNPRas-related protein Rap-1b/0.494
2gcpGSPRho-related GTP-binding protein RhoC/0.493
3cphGDPRas-related protein SEC4/0.493
3rs7GNPGTPase HRas/0.493
4dlsGNPGTPase HRas/0.493
1kmqGNPTransforming protein RhoA/0.492
3oiuGNPGTPase HRas/0.491
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.491
1cxzGSPTransforming protein RhoA/0.490
3x1zGNPRas-related protein Rap-1b/0.490
4xoiGTPTransforming protein RhoA/0.490
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.488
1zc3GNPRas-related protein Ral-A/0.485
1zd9GDPADP-ribosylation factor-like protein 8A/0.482
3tklGTPRas-related protein Rab-1A/0.482
3kudGDPGTPase HRas/0.481
3oivGNPGTPase HRas/0.481
4kvgGTPRas-related protein Rap-1A/0.481
4nyiGNPGTPase HRas/0.481
2rgcGNPGTPase HRas/0.479
3kucGDPRas-related protein Rap-1A/0.478
3pitGNPRas-related protein M-Ras/0.478
4mitGTPRho-related protein racC/0.477
3rs4GNPGTPase HRas/0.476
3rslGNPGTPase HRas/0.476
1ibrGNPGTP-binding nuclear protein Ran/0.475
1oixGDPRas-related protein Rab-11A/0.475
3lbhGNPGTPase HRas/0.474
3tnfGNPRas-related protein Rab-8A/0.474
4dxaGSPRas-related protein Rap-1b/0.474
3eg5GNPCell division control protein 42 homolog/0.471
1k5dGNPGTP-binding nuclear protein Ran/0.470
1zc4GNPRas-related protein Ral-A/0.469
4js0GNPCell division control protein 42 homolog/0.469
3rs0GNPGTPase HRas/0.465
4dlxGNPGTPase HRas/0.465
4dlzGNPGTPase HRas/0.465
1a2bGSPTransforming protein RhoA/0.464
3kkoGNPRas-related protein M-Ras/0.464
1m7bGTPRho-related GTP-binding protein RhoE/0.463
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.463
2rgbGNPGTPase HRas/0.461
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.461
1lfdGNPGTPase HRas/0.459
2clsGTPRho-related GTP-binding protein Rho6/0.459
4dsnGCPGTPase KRas/0.457
3lbiGNPGTPase HRas/0.455
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.455
1d5cGDPGTPase (Rab6)/0.451
1z2cGNPRho-related GTP-binding protein RhoC/0.451
3k8yGNPGTPase HRas/0.450
2bbwGP5Adenylate kinase 4, mitochondrial/0.449
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.449
2olrATPPhosphoenolpyruvate carboxykinase (ATP)/0.448
3kz1GSPTransforming protein RhoA/0.448
4ohvANPProtein clpf-1/0.447
3th5GNPRas-related C3 botulinum toxin substrate 1/0.446
4o2lGTPGTP-binding protein Rheb/0.446
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.445
1z0aGDPRas-related protein Rab-2A/0.445
3mjhGTPRas-related protein Rab-5A/0.445
1s1cGNPTransforming protein RhoA/0.444
1n6lGTPRas-related protein Rab-5A/0.443
4l9wGNPGTPase HRas/0.443
4panGDPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.443
4uj3GNPRas-related protein Rab-11A/0.443
2uxoTACHTH-type transcriptional regulator TtgR/0.441
3t1tGDPProbable gliding protein mglA/0.441
5hpyGDPTransforming protein RhoA/0.441
4ohxADPProtein clpf-1/0.440