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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1sstCOASerine acetyltransferase2.3.1.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1sstCOASerine acetyltransferase2.3.1.301.000
4n6bCOAUncharacterized protein/0.553
3t14FADSulfide-quinone reductase/0.458
5mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.451
3syiFADSulfide-quinone reductase/0.450
3t2yFADSulfide-quinone reductase/0.449
1xddAAYIntegrin alpha-L/0.448
5a1tNAIL-lactate dehydrogenase/0.447
3t2zFADSulfide-quinone reductase/0.446
4ajp88NL-lactate dehydrogenase A chain1.1.1.270.446
1kkq471Peroxisome proliferator-activated receptor alpha/0.445
2znnS44Peroxisome proliferator-activated receptor alpha/0.445
2fznFADBifunctional protein PutA1.5.5.20.444
3sz0FADSulfide-quinone reductase/0.443
2hjrAPRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase/0.441
3kpkFADSulfide-quinone reductase/0.440
4wluNADMalate dehydrogenase, mitochondrial1.1.1.370.440