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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1s1rNAPAldo-keto reductase family 1 member C3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1s1rNAPAldo-keto reductase family 1 member C3/1.000
4dz5NAPAldo-keto reductase family 1 member C3/0.623
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.542
4xo7NAPAldo-keto reductase family 1 member C2/0.534
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.523
4jtqNAPAldo-keto reductase family 1 member C2/0.523
4jq3NAPAldo-keto reductase family 1 member C2/0.509
1s1pNAPAldo-keto reductase family 1 member C3/0.503
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.501
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.500
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.496
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.495
2hdjNDPAldo-keto reductase family 1 member C2/0.489
2hejNDPAldo-keto reductase family 1 member C211.1.10.489
4l1xNAPAldo-keto reductase family 1 member C2/0.475
3h7rNAPAldo-keto reductase family 4 member C8/0.466
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.464
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.464
1ah4NAPAldose reductase1.1.1.210.452
2p5nNDPAldo-keto reductase family 1 member C211.1.10.446
3o3rNAPAldose reductase-related protein 11.1.1.210.444
2iq0NAPAldose reductase1.1.1.210.441